公开(公告)号：US10774157B2

公开(公告)日：2020-09-15

申请号：US15779424

申请日：2016-12-01

Applicant: UCB BIOPHARMA SPRL

Inventor： Michael John Wright

IPC: C07K16/28 ,  C07K16/00 ,  C07K16/46 ,  C07K16/14 ,  C07K14/39

Abstract: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A(A1)n-X:Y-B(B1)m and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets. Such complexes may be used to capture soluble molecules secreted from a particular cell, in therapy, in research and for experimental purposes such as in assays to characterise patient populations by identifying cell populations relevant to a pathology or prognosis.

公开(公告)号：US10730952B2

公开(公告)日：2020-08-04

申请号：US15326499

申请日：2015-07-16

Applicant: UCB BIOPHARMA SPRL

Inventor： Helene Margaret Finney ,  Stephen Edward Rapecki ,  Michael John Wright ,  Kerry Louise Tyson

IPC: A61K39/00 ,  C07K16/28 ,  C07K16/18 ,  C07K16/46

Abstract: The present disclosure relates to a multispecific molecule comprising a binding domain specific to the antigen CD45 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising same and use of each in treatment, for example treatment of autoimmune disease.

公开(公告)号：US20210301012A1

公开(公告)日：2021-09-30

申请号：US16342800

申请日：2017-10-23

Applicant: UCB Biopharma SPRL

Inventor： Michael John Wright ,  Ralph Adams ,  Rebecca Burnley ,  Anna Ettorre

IPC: C07K16/24

Abstract: The invention is in the field of protein:protein interactions, in particular the stabilisation of protein:protein interactions. Binding proteins are provided for stabilising the interactions, together with compositions comprising the binding proteins. Methods using the binding proteins are also provided, including targeting of cells and also medical uses.

公开(公告)号：US10590197B2

公开(公告)日：2020-03-17

申请号：US15743756

申请日：2016-07-15

Applicant: UCB Biopharma SPRL

Inventor： Helene Margaret Finney ,  Stephen Edward Rapecki ,  Kerry Louise Tyson ,  Michael John Wright

IPC: C07K16/28 ,  A61K39/00 ,  A01K67/027

Abstract: The present disclosure relates to antibody molecules comprising a binding domain specific to CD22, said binding domain comprising SEQ ID NO: 1, 2, 3, 4, 5 and 6 or 7. The disclosure also extends to pharmaceutical compositions comprising said antibody molecules and use of the antibody molecules/compositions in treatment.

公开(公告)号：US11692041B2

公开(公告)日：2023-07-04

申请号：US15743761

申请日：2016-07-15

Applicant: UCB Biopharma SPRL

Inventor： Helene Margaret Finney ,  Stephen Edward Rapecki ,  Kerry Louise Tyson ,  Michael John Wright

IPC: C07K16/30 ,  C07K16/28 ,  C07K16/46 ,  C07K16/18

CPC classification number: C07K16/289 ,  C07K16/18 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/90

Abstract: The present disclosure relates to constructs, such as antibody molecules comprising a binding domain specific to CD45, said binding domain comprising SEQ ID NO: 1, 2, 3 and/or SEQ ID NO: 4, 5 and 6. The disclosure also extends to pharmaceutical compositions comprising said constructs and use of the constructs/compositions in treatment.

公开(公告)号：US10370447B2

公开(公告)日：2019-08-06

申请号：US15326501

申请日：2015-07-16

Applicant: UCB BIOPHARMA SPRL

Inventor： Helene Margaret Finney ,  Stephen Edward Rapecki ,  Michael John Wright ,  Kerry Louise Tyson

IPC: C07K16/28 ,  C07K16/18 ,  A61K39/00

Abstract: The present disclosure relates to multispecific molecule comprising a binding domain specific to the antigen CD22 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising the same and use of both in treatment, for example the treatment of autoimmune disease.

公开(公告)号：US11286312B2

公开(公告)日：2022-03-29

申请号：US15779417

申请日：2016-12-01

Applicant: UCB BIOPHARMA SPRL

Inventor： Pallavi Bhatta ,  Laura Starkie ,  Michael John Wright

IPC: C07K16/46 ,  C07K16/14 ,  C07K14/395 ,  C07K16/00 ,  C12N15/10

Abstract: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A-X:Y-B) and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets.

公开(公告)号：US10774152B2

公开(公告)日：2020-09-15

申请号：US15326499

申请日：2015-07-16

Applicant: UCB BIOPHARMA SPRL

Inventor： Helene Margaret Finney ,  Stephen Edward Rapecki ,  Michael John Wright ,  Kerry Louise Tyson

IPC: A61K39/00 ,  C07K16/28 ,  C07K16/18 ,  C07K16/46

Abstract: The present disclosure relates to a multispecific molecule comprising a binding domain specific to the antigen CD45 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising same and use of each in treatment, for example treatment of autoimmune disease.

公开(公告)号：US10358493B2

公开(公告)日：2019-07-23

申请号：US15311198

申请日：2015-05-28

Applicant: UCB BIOPHARMA SPRL

Inventor： Helene Margaret Finney ,  Stephen Edward Rapecki ,  Michael John Wright

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/14 ,  C07K16/46 ,  G01N33/68

Abstract: The present disclosure relates to a novel bispecific protein complex and a method of using the complexes to screen for synergistic or novel biological function. The bispecific format is particularly suitable for high-throughput screening because all of its components can be expressed from cells as individual units and the units can be assembled simply by mixing without employing conjugation or coupling chemistry.