公开(公告)号：US11078196B2

公开(公告)日：2021-08-03

申请号：US16438348

申请日：2019-06-11

Applicant: UCB Biopharma SRL

Inventor： Wolfgang Wrasidlo ,  Emily M. Stocking

IPC: C07D417/12 ,  C07D417/14 ,  C07D403/12 ,  C07D413/12

Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.

公开(公告)号：US10975066B2

公开(公告)日：2021-04-13

申请号：US15748154

申请日：2016-07-29

Applicant: UCB Biopharma SRL

Inventor： Wolfgang Wrasidlo ,  Emily M. Stocking ,  Adrian Hall ,  Malcolm Maccoss

IPC: C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  A61P25/28

Abstract: The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.