公开(公告)号：US20240043400A1

公开(公告)日：2024-02-08

申请号：US18265156

申请日：2021-12-01

Applicant: UCB Biopharma SRL

Inventor： Ali Ates ,  Pierre Burssens ,  Adrian Hall ,  Laurent Provins ,  David Skolc ,  Anne Valade

IPC: C07D401/06 ,  C07D217/04 ,  C07D471/04 ,  C07D401/10

CPC classification number: C07D401/06 ,  C07D217/04 ,  C07D471/04 ,  C07D401/10

Abstract: The present invention relates to octahydroisoquinolinyl derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US10913735B2

公开(公告)日：2021-02-09

申请号：US16480252

申请日：2018-01-23

Applicant: UCB Biopharma SRL

Inventor： Adrian Hall

IPC: C07D417/14 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61P25/28 ,  A61P25/16

Abstract: The present invention relates to bis-heteroaryl compounds of formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

公开(公告)号：US11091474B2

公开(公告)日：2021-08-17

申请号：US16480251

申请日：2018-01-23

Applicant: UCB Biopharma SRL

Inventor： Adrian Hall ,  Malcolm Maccoss

IPC: C07D417/14

Abstract: The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

公开(公告)号：US10975066B2

公开(公告)日：2021-04-13

申请号：US15748154

申请日：2016-07-29

Applicant: UCB Biopharma SRL

Inventor： Wolfgang Wrasidlo ,  Emily M. Stocking ,  Adrian Hall ,  Malcolm Maccoss

IPC: C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  A61P25/28

Abstract: The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

公开(公告)号：US20240083875A1

公开(公告)日：2024-03-14

申请号：US18267324

申请日：2021-12-16

Applicant: UCB BIOPHARMA SRL

Inventor： Adrian Hall

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: The present invention relates to tetrahydroisoquinolinyl derivatives of formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US10889584B2

公开(公告)日：2021-01-12

申请号：US16480254

申请日：2018-01-23

Applicant: UCB Biopharma SRL

Inventor： Adrian Hall ,  Laurent Provins ,  Malcolm Maccoss

IPC: C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61P25/28

Abstract: The present invention relates to certain bicyclic bis-heteroaryl compounds of Formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.