公开(公告)号：US20210053952A1

公开(公告)日：2021-02-25

申请号：US16959339

申请日：2019-01-10

Applicant: UCB Biopharma SRL

Inventor： Gareth Neil Brace ,  Rose Elizabeth Chappell ,  Gregory Foulkes ,  James Richard Frost ,  Helen Tracey Horsley ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Monika-Sarah Elizabeth Dorothea Schulze ,  Richard David Taylor ,  Wei Tsung Yau ,  Zhaoning Zhu

IPC: C07D407/14 ,  C07D413/12 ,  C07D413/14 ,  C07D235/16 ,  C07D401/14

Abstract: A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US11472794B2

公开(公告)日：2022-10-18

申请号：US16959339

申请日：2019-01-10

Applicant: UCB Biopharma SRL

Inventor： Gareth Neil Brace ,  Rose Elizabeth Bardell-Cox ,  Gregory Foulkes ,  James Richard Frost ,  Helen Tracey Horsley ,  Elizabeth Pearl Jones ,  Fabien Claude Lecomte ,  James Thomas Reuberson ,  Monika-Sarah Elizabeth Dorothea Schulze ,  Richard David Taylor ,  Wei Tsung Yau ,  Zhaoning Zhu

IPC: C07D403/12 ,  C07D413/12 ,  C07D407/14 ,  C07D235/16 ,  C07D401/14 ,  C07D413/14

Abstract: A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

公开(公告)号：US20230399328A1

公开(公告)日：2023-12-14

申请号：US18035332

申请日：2021-11-01

Applicant: UCB Biopharma SRL

Inventor： James Richard Frost ,  Gregory William Haslett ,  James Thomas Reuberson

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A series of substituted dicyclopropyl methyl derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.