公开(公告)号：US20160108119A1

公开(公告)日：2016-04-21

申请号：US14977688

申请日：2015-12-22

申请人： UCB PHARMA, S.A.

发明人： Mariangela Spitali ,  Jonathan Symmons ,  Richard Whitcombe ,  Mark Robert Pearce-Higgins

IPC分类号： C07K16/24 ,  C07K1/18

CPC分类号： C07K16/241 ,  C07K1/18 ,  C07K1/36 ,  C07K2317/14 ,  C07K2317/55

摘要： The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.

公开(公告)号：US11339214B2

公开(公告)日：2022-05-24

申请号：US16248845

申请日：2019-01-16

申请人： UCB PHARMA, S.A.

发明人： Mariangela Spitali ,  Jonathan Symmons ,  Richard Whitcombe ,  Mark Robert Pearce-Higgins

IPC分类号： C07K1/18 ,  C07K16/24 ,  C07K1/36

摘要： The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.

公开(公告)号：US10189897B2

公开(公告)日：2019-01-29

申请号：US14977688

申请日：2015-12-22

申请人： UCB PHARMA, S.A.

发明人： Mariangela Spitali ,  Jonathan Symmons ,  Richard Whitcombe ,  Mark Robert Pearce-Higgins

IPC分类号： C07K1/18 ,  C07K1/36 ,  C07K16/24

摘要： The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.

公开(公告)号：US20190135909A1

公开(公告)日：2019-05-09

申请号：US16248845

申请日：2019-01-16

申请人： UCB PHARMA, S.A.

发明人： Mariangela Spitali ,  Jonathan Symmons ,  Richard Whitcombe ,  Mark Robert Pearce-Higgins

IPC分类号： C07K16/24 ,  C07K1/36 ,  C07K1/18

摘要： The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.