公开(公告)号：US20150191537A1

公开(公告)日：2015-07-09

申请号：US14662538

申请日：2015-03-19

Applicant: UCB PHARMA S.A.

Inventor： DAVID G. WINKLER ,  JIYE SHI ,  JOHN LATHAM

IPC: C07K16/22 ,  A61K47/48 ,  G01N33/68 ,  C07K14/475

CPC classification number: C07K16/22 ,  A61K47/643 ,  A61K47/646 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2317/76 ,  G01N33/6854 ,  G01N2333/4704

Abstract: Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.