公开(公告)号：US20250129065A1

公开(公告)日：2025-04-24

申请号：US18667825

申请日：2024-05-17

Applicant: UCL Business LTD.

Inventor： Stephen Neidle ,  Richard Angell ,  Sally Oxenford

IPC: C07D471/04 ,  A61P35/00

Abstract: The present invention relates to naphthalene diimides, NDIs, and methods of synthesising them. The NDIs have DNA-quadruplex binding and stabilising activity, and potential in treatment of pancreatic, prostate, and other human cancers. The NDIs are a compound of Formula I:

公开(公告)号：US20230212166A1

公开(公告)日：2023-07-06

申请号：US18089498

申请日：2022-12-27

Applicant: UCL Business LTD.

Inventor： Stephen Neidle ,  Richard Angell ,  Sally Oxenford

IPC: C07D471/04 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61P35/00

Abstract: The present invention relates to naphthalene diimides, NDIs, and methods of synthesising them. The NDIs have DNA-quadruplex binding and stabilising activity, and potential in treatment of pancreatic, prostate, and other human cancers. The NDIs are a compound of Formula I:

公开(公告)号：US11560380B2

公开(公告)日：2023-01-24

申请号：US17611890

申请日：2020-05-15

Applicant: UCL Business Ltd

Inventor： Stephen Neidle ,  Richard Angell ,  Sally Oxenford

IPC: C07D471/04 ,  A61P35/00

Abstract: The present invention relates to naphthalene diimides, NDIs, and methods of synthesising them. The NDIs have DNA-quadruplex binding and stabilising activity, and potential in treatment of pancreatic, prostate, and other human cancers. The NDIs are a compound of Formula I.