公开(公告)号：US20250011445A1

公开(公告)日：2025-01-09

申请号：US18030974

申请日：2021-10-08

Applicant: UCL BUSINESS LTD ,  UNIVERSITÄT ZU KÖLN ,  FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA ARAGÓN ,  FUNDACIÓN AGENCIA ARAGONESA PARA LA INVESTIGACIÓN Y EL DESARROLLO ,  UNIVERSIDAD DE ZARAGOZA

Inventor： Michael BERGMANN ,  Diego DE MIGUEL SAMANIEGO ,  Gianmaria LICCARDI ,  Julian PARDO JIMENO ,  Nieves PELTZER ,  Maria SECRIER ,  Lucia TARABORRELLI ,  Henning WALCZAK

IPC: C07K16/28 ,  A61K31/167 ,  A61K31/192 ,  A61K31/275 ,  A61K31/573 ,  A61K31/616 ,  A61K39/00 ,  A61K45/06 ,  A61P31/14 ,  C07K16/24

Abstract: The invention provides methods and means for the inhibition or neutralisation of death receptor/death ligand members of the tumour necrosis factor superfamil and TNF receptor superfamilies and/or the Toll-like receptor family, and/or NOD-like receptor and/or of the signalling induced via these receptors, preferably in combination with each other and/or with anti-inflammatory agents, in treating diseases such as Acute Respiratory Distress Syndrome (ARDS), such as that caused by airway-targeting viruses, such as SARS coronaviruses.

公开(公告)号：US20240424023A1

公开(公告)日：2024-12-26

申请号：US18690333

申请日：2022-09-09

Applicant: Pietro Genovese ,  UCL BUSINESS LTD

Inventor： Pietro Genovese ,  Thomas Fox ,  Emma Morris ,  Claire Booth ,  Ben Houghton

IPC: A61K35/17 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

Abstract: The present invention provides a method of engineering a cell, comprising the steps of introducing into the cell: i) a site-directed nuclease which is capable of cleaving a target nucleotide sequence at the 3′-end of Intron 1 of a Cytotoxic T-Lymphocyte Associated Protein 4 gene (CTLA4); and ii) a nucleic acid construct which comprises a nucleic acid sequence comprising one or more of exon 2, exon 3 and exon 4 of CTLA4, or a sequence with at least 70% identity to exon 2, exon 3 and/or exon 4 of the CTLA4 gene, and 5′- and 3′-homology arms, wherein each of the 5′ and '3 homology arms is essentially complementary to a sequence flanking the target nucleotide sequence at the 3′-end of Intron 1 of CTLA4.

公开(公告)号：US20240404235A1

公开(公告)日：2024-12-05

申请号：US18694735

申请日：2022-09-22

Applicant: UCL BUSINESS LTD.

Inventor： Watjana LILAONITKUL ,  Adam DUBIS ,  James WILLOUGHBY

IPC: G06V10/25 ,  G06V10/26 ,  G06V10/30 ,  G06V10/77 ,  G06V10/774 ,  G06V10/82

Abstract: A computer-implemented method of enhancing object detection in a digital image of known underlying structure using pre-processed images with underlying structure and with any objects detected and bounding boxes inserted over the objects, the method comprising: extracting or generating images with the underlying structure but without objects detected as negative images; extracting images with the underlying structure and with an object detected as positive images; inputting pairs of negative and positive images through a feature extraction section in a neural network to extract feature vectors of the images; contrasting feature vectors of each pair of positive and negative images and thereby provide a contrast vector and gating the result to form an attention vector; processing the attention vector and the feature vector of the positive image to produce an output.

公开(公告)号：US20240382585A1

公开(公告)日：2024-11-21

申请号：US18742842

申请日：2024-06-13

Applicant: London School of Hygiene & Tropical Medicine ,  UCL Business LTD

Inventor： Brendan WREN ,  Jeremy BROWN ,  Jon CUCCUI

IPC: A61K39/385 ,  A61K39/00 ,  A61K39/09 ,  A61K47/64 ,  A61P31/04 ,  C07K14/315

Abstract: This invention relates to the use of S. pneumoniae protein antigens, such as NanA, PluA and Sp0148, as carriers for immunogenic S. pneumoniae capsular polysaccharide. This may be useful for example in glycoconjugate vaccines able to generate a protective immune response against multiple capsuler serotypes. Glycoconjugates, vaccine compositions and methods of manufacture and use are provided.

公开(公告)号：US20240374757A1

公开(公告)日：2024-11-14

申请号：US18554454

申请日：2022-04-19

Applicant: UCL Business Ltd

Inventor： Liam KEMPTHORNE ,  Adrian ISAACS

IPC: A61K48/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86

Abstract: Provided herein is a composition comprising (i) a nucleic acid sequence encoding a CasRx/Cas13d polypeptide; and (ii) a guide RNA that binds specifically to a target sequence in C9orf72 RNA. Also provided are associated pharmaceutical compositions, guide RNAs, complexes, vectors and cells, and uses of the compositions to neurodegenerative disorders.

公开(公告)号：US12138318B2

公开(公告)日：2024-11-12

申请号：US16541516

申请日：2019-08-15

Applicant: UCL Business LTD

Inventor： Amit Nathwani ,  Allison Dane

IPC: A61K48/00 ,  C07K14/005 ,  C12N15/86

Abstract: There is described an AAV capsid protein having an amino acid sequence which has at least 98% identity to the sequence of SEQ ID NO: 3 or at least 94% identity to the sequence of SEQ ID NO: 4. Also described is a pharmaceutical composition, an AAV capsid and a viral particle comprising the capsid protein, a recombinant AAV vector comprising a nucleotide sequence which encodes for the capsid protein, and a host cell and a transgenic animal comprising the capsid protein or the vector. In addition, there is described a method of transferring a nucleic acid of interest into a mammal comprising introducing a recombinant AAV vector into the mammal, wherein the recombinant AAV vector comprises a gene of interest which is encapsidated into a capsid comprising the capsid protein.

公开(公告)号：US20240345086A1

公开(公告)日：2024-10-17

申请号：US18579635

申请日：2022-07-20

Applicant: UCL Business LTD

Inventor： Kevin Mills ,  Wendy Heywood ,  Ivan Doykov ,  James Moon

IPC: G01N33/569 ,  G01N33/68

CPC classification number: G01N33/56983 ,  G01N33/6848 ,  G01N2333/165 ,  G01N2469/20

Abstract: The present invention relates to a high throughput targeted proteomics-based method for identifying and quantifying one or more binding molecules in a biological fluid of an individual. The present invention involves the use of a plurality of bait molecules to capture the binding molecules. The invention uses proteomics techniques, such as mass spectrometry, for the identification and quantification of the binding molecules. The methods of the invention can be used to identify and quantify antibodies produced by an individual, and proteins expressed by an individual, following exposure to antigens, such as viral antigens, particularly coronavirus antigens and more particularly SARS-CoV-2. Exposure may be via vaccination or following natural infection. The methods of the invention can be used to identify and quantify molecules which bind to a range of proteins of interest, such as autoantigens and neoantigens, as well as to viral vectors.

公开(公告)号：US12102431B2

公开(公告)日：2024-10-01

申请号：US17054189

申请日：2018-05-25

Applicant: TOYOTA MOTOR EUROPE ,  UCL BUSINESS LTD

Inventor： Jonas Ambeck-Madsen ,  Nilli Lavie ,  Merit Bruckmaier ,  Ilias Tachtsidis

IPC: A61B5/18 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455

CPC classification number: A61B5/14553 ,  A61B5/0048 ,  A61B5/14546 ,  A61B5/18 ,  A61B5/4064

Abstract: A method of determining the perceptual load of a human brain. The perceptual load is induced by a predetermined task carried out by the human. The method includes the steps of: measuring with a functional near-infrared spectroscopy (fNIRS) sensor device a metabolic activity of the human brain while the task is carried out and determining the perceptual load as a function of a measured change in metabolic activity. The invention further relates to a method of determining the level of stimulus perception corresponding systems.

公开(公告)号：US20240310619A1

公开(公告)日：2024-09-19

申请号：US18257389

申请日：2021-12-07

Applicant: UCL BUSINESS LTD

Inventor： Petru MANESCU ,  Delmiro FERNANDEZ-REYES

IPC: G02B21/36 ,  G02B21/26 ,  G06T7/00 ,  G06V20/69

CPC classification number: G02B21/367 ,  G02B21/26 ,  G06T7/0012 ,  G06V20/693 ,  G06T2207/10056 ,  G06T2207/20081 ,  G06T2207/20084

Abstract: A computer implemented method of controlling a microscope (632) is provided. The method comprises capturing an image (631) within a field of view of a lens of the microscope (632) configured to view a sample on a motorised stage (633) of the microscope (632). The image comprises a portion of the sample. The image (631) is provided to an artificial neural network (610). An action (611) for moving the motorised stage (633) is determined in dependence on an output of the artificial neural network (610). The motorised stage (633) is moved automatically in accordance with the action (611).

公开(公告)号：US20240280530A1

公开(公告)日：2024-08-22

申请号：US18570995

申请日：2022-06-17

Applicant: UCL BUSINESS LTD

Inventor： Stefan HOWORKA ,  Yongzheng XING

IPC: G01N27/327

CPC classification number: G01N27/3278

Abstract: A membrane-spanning actuatable nucleic acid nanopore is provided. The nanopore comprises: one or more polynucleotide strands that provide a scaffold component and a plurality of polynucleotide strands that provide a plurality of staple components wherein each of the plurality of staple components hybridise to the scaffold component; and a trigger that is actuatable in response to a stimulus. Actuation of the trigger results in a detectable conformational change of the nanopore from a first conformation to at least a second conformation. Detection may be via a signal change, such as via fluorescence (e.g. FRET) or a change in an electrical signal readout. Semi-fluid membranes, and sensor devices comprising the actuatable nucleic acid nanopores are also provided.