公开(公告)号：US20140178456A1

公开(公告)日：2014-06-26

申请号：US14194813

申请日：2014-03-02

Applicant: UDAYA SANKAR DEVANABOYINA

Inventor： UDAYA SANKAR DEVANABOYINA

IPC: A61K31/4439 ,  A61K9/00

CPC classification number: A61K31/4439 ,  A61K9/0024 ,  A61K47/14 ,  A61K47/22 ,  A61K47/34

Abstract: In some embodiments, there are provided methods and compositions for treating, preventing, or delaying the onset of type 2 diabetes and related disorders. The methods comprise administering a sustained release composition comprising a peroxisome proliferator-activated receptor (PPAR) agonist subcutaneously in a localized area of the subject. Slow release of the PPAR agonist in situ enhances the metabolic activity of subcutaneous adipose tissue, resulting in an increased ability of the tissue to clear excess glucose and lipid from the blood stream, while minimizing adverse side-effects of the agonist.

Abstract translation: 在一些实施方案中，提供了用于治疗，预防或延迟2型糖尿病和相关病症发作的方法和组合物。 所述方法包括在受试者的局部区域中皮下投与包含过氧化物酶体增殖物激活受体（PPAR）激动剂的持续释放组合物。 PPAR激动剂的缓慢释放原位增强皮下脂肪组织的代谢活性，导致组织从血液中清除过量的葡萄糖和脂质的能力增加，同时最小化激动剂的不利副作用。