公开(公告)号：US20110263678A1

公开(公告)日：2011-10-27

申请号：US13028035

申请日：2011-02-15

申请人： ULRICH BOGDAHN ,  Ludwig Aigner ,  Frank-Peter Wachs ,  Beate Winner ,  Jürgen Winkler

发明人： ULRICH BOGDAHN ,  Ludwig Aigner ,  Frank-Peter Wachs ,  Beate Winner ,  Jürgen Winkler

IPC分类号： A61K31/7105 ,  A61P25/18 ,  A61P27/06 ,  A61P25/24 ,  C07H21/04 ,  A61P25/28

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C07K14/71 ,  C12N2310/11

摘要： The present invention relates to the use of oligonucleotides for the preparation of a pharmaceutical composition for the prevention or treatment of a disease, wherein neurogenesis and/or neuroregeneration has a beneficial effect, in particular a disease like Morbus Alzheimer, Morbus Parkinson, Lewy Body Dementia,—Amyotrophic Lateral Sclerosis, Spinocerebellar Atrophies, Creutzfeldt Jakob Disease, Frontemporal Dementia, Morbus Pick, AIDS Dementia Complex, Vascular Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Multisystem-Atrophy, Hallervorden Spatz Disease, Huntington's disease, Stroke, Traumatic Brain and spinal cord Injury, Retinitis Pigmentosa, Macular Degeneration, Glaucoma, Cochlea Degeneration, Depression, Schizophrenia, Multiple Sclerosis, and developmental neurodegeneration.

摘要翻译： 本发明涉及寡核苷酸用于制备用于预防或治疗疾病的药物组合物的用途，其中神经发生和/或神经再生具有有益效果，特别是诸如Morbus阿尔茨海默氏症，Morbus帕金森氏病，路易体痴呆症 ，肌营养不良性侧索硬化症，脊髓小脑萎缩症，Creutzfeldt雅各布病，前痴呆症，Morbus Pick，艾滋病痴呆综合征，血管性痴呆，进行性核核性麻痹，皮质基底退化，多系统萎缩，Hallervorden Spatz病，亨廷顿氏病，中风，创伤性脑和脊髓 脐带损伤，视网膜色素变性，黄斑变性，青光眼，耳蜗变性，抑郁，精神分裂症，多发性硬化和发育性神经变性。