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公开(公告)号：US20110263678A1
公开(公告)日：2011-10-27
申请号：US13028035
申请日：2011-02-15
CPC分类号： C12N15/1138 , A61K38/00 , C07K14/71 , C12N2310/11
摘要： The present invention relates to the use of oligonucleotides for the preparation of a pharmaceutical composition for the prevention or treatment of a disease, wherein neurogenesis and/or neuroregeneration has a beneficial effect, in particular a disease like Morbus Alzheimer, Morbus Parkinson, Lewy Body Dementia,—Amyotrophic Lateral Sclerosis, Spinocerebellar Atrophies, Creutzfeldt Jakob Disease, Frontemporal Dementia, Morbus Pick, AIDS Dementia Complex, Vascular Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Multisystem-Atrophy, Hallervorden Spatz Disease, Huntington's disease, Stroke, Traumatic Brain and spinal cord Injury, Retinitis Pigmentosa, Macular Degeneration, Glaucoma, Cochlea Degeneration, Depression, Schizophrenia, Multiple Sclerosis, and developmental neurodegeneration.
摘要翻译： 本发明涉及寡核苷酸用于制备用于预防或治疗疾病的药物组合物的用途，其中神经发生和/或神经再生具有有益效果，特别是诸如Morbus阿尔茨海默氏症，Morbus帕金森氏病，路易体痴呆症 ，肌营养不良性侧索硬化症，脊髓小脑萎缩症，Creutzfeldt雅各布病，前痴呆症，Morbus Pick，艾滋病痴呆综合征，血管性痴呆，进行性核核性麻痹，皮质基底退化，多系统萎缩，Hallervorden Spatz病，亨廷顿氏病，中风，创伤性脑和脊髓 脐带损伤，视网膜色素变性，黄斑变性，青光眼，耳蜗变性，抑郁，精神分裂症，多发性硬化和发育性神经变性。
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公开(公告)号：US08022045B1
公开(公告)日：2011-09-20
申请号：US10597813
申请日：2005-02-09
CPC分类号： C12N15/1138 , A61K38/00 , C07K14/71 , C12N2310/11
摘要： The present invention relates to the use of oligonucleotides for the preparation of a pharmaceutical composition for the prevention or treatment of a disease, wherein neurogenesis and/or neuroregeneration has a beneficial effect, in particular a disease like Morbus Alzheimer, Morbus Parkinson, Lewy Body Dementia, Amyotrophic Lateral Sclerosis, Spinocerebellar Atrophies, Creutzfeldt Jakob Disease, Frontemporal Dementia, Morbus Pick, AIDS Dementia Complex, Vascular Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Multisystem-Atrophy, Hallervorden Spatz Disease, Huntington's disease, Stroke, Traumatic Brain and spinal cord Injury, Retinitis Pigmentosa, Macular Degeneration, Glaucoma, Cochlea Degeneration, Depression, Schizophrenia, Multiple Sclerosis, and developmental neurodegeneration.
摘要翻译： 本发明涉及寡核苷酸用于制备用于预防或治疗疾病的药物组合物的用途，其中神经发生和/或神经再生具有有益效果，特别是诸如Morbus阿尔茨海默氏症，Morbus帕金森氏病，路易体痴呆症 ，肌萎缩性侧索硬化症，脊髓小脑萎缩症，Creutzfeldt雅各布病，前痴呆症，Morbus拣选，艾滋病痴呆复合物，血管性痴呆，进行性核核麻痹，皮质基底变性，多系统萎缩，霍氏阴道病，亨廷顿病，中风，创伤性脑和脊髓 损伤，色素性视网膜炎，黄斑变性，青光眼，耳蜗变性，抑郁，精神分裂症，多发性硬化和发育性神经变性。
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公开(公告)号：US08283334B2
公开(公告)日：2012-10-09
申请号：US13028035
申请日：2011-02-15
CPC分类号： C12N15/1138 , A61K38/00 , C07K14/71 , C12N2310/11
摘要： The present invention relates to the use of oligonucleotides for the preparation of a pharmaceutical composition for the prevention or treatment of a disease, wherein neurogenesis and/or neuroregeneration has a beneficial effect, in particular a disease like Morbus Alzheimer, Morbus Parkinson, Lewy Body Dementia, Amyotrophic Lateral Sclerosis, Spinocerebellar Atrophies, Creutzfeldt Jakob Disease, Frontemporal Dementia, Morbus Pick, AIDS Dementia Complex, Vascular Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Multisystem-Atrophy, Hallervorden Spatz Disease, Huntington's disease, Stroke, Traumatic Brain and spinal cord Injury, Retinitis Pigmentosa, Macular Degeneration, Glaucoma, Cochlea Degeneration, Depression, Schizophrenia, Multiple Sclerosis, and developmental neurodegeneration.
摘要翻译： 本发明涉及寡核苷酸用于制备用于预防或治疗疾病的药物组合物的用途，其中神经发生和/或神经再生具有有益效果，特别是诸如Morbus阿尔茨海默氏症，Morbus帕金森氏病，路易体痴呆症 ，肌萎缩性侧索硬化症，脊髓小脑萎缩症，Creutzfeldt雅各布病，前痴呆症，Morbus拣选，艾滋病痴呆复合物，血管性痴呆，进行性核核麻痹，皮质基底变性，多系统萎缩，霍氏阴道病，亨廷顿病，中风，创伤性脑和脊髓 损伤，色素性视网膜炎，黄斑变性，青光眼，耳蜗变性，抑郁，精神分裂症，多发性硬化和发育性神经变性。
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4.发明授权Use of regulatory sequences for specific, transient expression in neuronal determined cells 有权在神经元确定的细胞中使用调节序列用于特异性，瞬时表达公开(公告)号：US08841430B2
公开(公告)日：2014-09-23
申请号：US12894766
申请日：2010-09-30
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译： 本发明涉及调节序列用于介导增殖性神经元测定细胞中特异性，早期瞬时表达的用途。 此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异的早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。 此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。 本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。 另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。 最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。
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5.发明申请USE OF REGULATORY SEQUENCES FOR SPECIFIC, TRANSIENT EXPRESSION IN NEURONAL DETERMINED CELLS 有权神经元测定细胞中特异性，瞬时表达的调节序列的使用公开(公告)号：US20110016547A1
公开(公告)日：2011-01-20
申请号：US12894766
申请日：2010-09-30
IPC分类号： A61K48/00 , C07H21/04 , C12N5/10 , C12N15/09 , A01K67/027 , C12N15/63 , A61K35/12 , C12Q1/68 , A61P35/00
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译： 本发明涉及调节序列用于介导增殖性神经元测定细胞中特异性，早期瞬时表达的用途。 此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异的早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。 此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。 本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。 另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。 最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。
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6.发明申请USE OF REGULATORY SEQUENCES FOR SPECIFIC, TRANSIENT EXPRESSION IN NEURONAL DETERMINED CELLS 有权神经元测定细胞中特异性，瞬时表达的调节序列的使用公开(公告)号：US20110020790A1
公开(公告)日：2011-01-27
申请号：US12894884
申请日：2010-09-30
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译： 本发明涉及调节序列用于介导增殖性神经元确定细胞中特异性，早期瞬时表达的用途。 此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异性早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。 此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。 本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。 另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。 最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。
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7.发明申请CHROMANE-LIKE CYCLIC PRENYLFLAVONOIDS FOR THE MEDICAL INTERVENTION IN NEUROLOGICAL DISORDERS 有权用于神经病学医疗干预的色素样循环性抗原公开(公告)号：US20140349919A1
公开(公告)日：2014-11-27
申请号：US14127029
申请日：2012-06-15
申请人： Ludwig Aigner , Eleni Oberbauer-Hofmann , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
发明人： Ludwig Aigner , Eleni Oberbauer-Hofmann , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
IPC分类号： C07D493/04 , C07D311/32 , C07D407/06 , C07D311/70
CPC分类号： A61K31/352 , A61K31/35 , A61K31/353 , A61K31/355 , A61K31/36 , C07D311/32 , C07D311/70 , C07D407/06 , C07D493/04
摘要： The present invention relates to certain chromane-like cyclic prenylflavonoids, in particular the compounds of formulae (I), (II) and (III) as described and defined herein, for use in the treatment or prevention of a neurological disorder, as well as their use in promoting neuronal differentiation, neurite outgrowth and neuroprotection.
摘要翻译： 本发明涉及某些苯甲酰样环状异戊烯基类黄酮，特别是本文所述和定义的式（I），（II）和（III）化合物，用于治疗或预防神经障碍，以及 它们用于促进神经元分化，神经突生长和神经保护。
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8.发明授权Use of regulatory sequences for specific, transient expression in neuronal determined cells 有权在神经元确定的细胞中使用调节序列用于特异性，瞬时表达公开(公告)号：US08815505B2
公开(公告)日：2014-08-26
申请号：US12894884
申请日：2010-09-30
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译： 本发明涉及调节序列用于介导增殖性神经元确定细胞中特异性，早期瞬时表达的用途。 此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异性早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。 此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。 本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。 另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。 最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。
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9.发明授权Use of regulatory sequences for specific, transient expression in neuronal determined cells 有权在神经元确定的细胞中使用调节序列用于特异性，瞬时表达公开(公告)号：US07947448B2
公开(公告)日：2011-05-24
申请号：US12209974
申请日：2008-09-12
IPC分类号： C12Q1/68 , A01K67/027 , C12N5/06
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译： 本发明涉及调节序列用于介导增殖性神经元确定细胞中特异性，早期瞬时表达的用途。 此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异性早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。 此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。 本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。 另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。 最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。
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10.发明授权公开(公告)号：US09956199B2
公开(公告)日：2018-05-01
申请号：US15354325
申请日：2016-11-17
发明人： Ludwig Aigner , Eleni Priglinger , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
IPC分类号： A61K31/35 , A61K31/352 , A61K31/353 , A61K31/36 , A61K31/355
CPC分类号： A61K31/352 , A61K31/35 , A61K31/353 , A61K31/355 , A61K31/36 , C07D311/32 , C07D311/70 , C07D407/06 , C07D493/04
摘要： The present invention relates to certain chromane-like cyclic prenylflavonoids, in particular the compounds of formulae (I), (II) and (III) as described and defined herein, for use in the treatment or prevention of a neurological disorder, as well as their use in promoting neuronal differentiation, neurite outgrowth and neuroprotection.
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