公开(公告)号：US20200306270A1

公开(公告)日：2020-10-01

申请号：US16899821

申请日：2020-06-12

申请人： UNION therapeutics A/S

发明人： Emilie Flora Aurore DELAVENNE ,  Daniel Jean Jacques SIMON ,  Morten Otto Alexander SOMMER ,  Rasmus Vendler TOFT-KEHLER

IPC分类号： A61K31/609 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K9/06 ,  A61P31/04 ,  A61P17/00

摘要： The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus, in particular Staphylococcus aureus, and Streptococcus, in particular Streptococcus pyogenes. Grain positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics.

公开(公告)号：US20200306271A1

公开(公告)日：2020-10-01

申请号：US16899830

申请日：2020-06-12

申请人： UNION therapeutics A/S

发明人： Emilie Flora Aurore DELAVENNE ,  Daniel Jean Jacques SIMON ,  Morten Otto Alexander SOMMER ,  Rasmus Vendler TOFT-KEHLER

IPC分类号： A61K31/609 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K9/06 ,  A61P31/04 ,  A61P17/00

摘要： The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus, in particular Staphylococcus aureus, and Streptococcus, in particular Streptococcus pyogenes. Grain positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics.

公开(公告)号：US20200306269A1

公开(公告)日：2020-10-01

申请号：US16899812

申请日：2020-06-12

申请人： UNION therapeutics A/S

发明人： Emilie Flora Aurore DELAVENNE ,  Daniel Jean Jacques SIMON ,  Morten Otto Alexander SOMMER ,  Rasmus Vendler TOFT-KEHLER

IPC分类号： A61K31/609 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K9/06 ,  A61P31/04 ,  A61P17/00

摘要： The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosam-ide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus, in particular Staphylococcus aureus, and Streptococcus, in particular Streptococcus pyogenesGrain positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appear-ance of resistant mutants compared to commonly used topical antibiotics.