-
公开(公告)号：US11529361B2
公开(公告)日：2022-12-20
申请号：US17091691
申请日：2020-11-06
IPC分类号： A61K31/609 , A61K31/612 , A61P31/04 , A61K45/06
摘要： The present invention relates to halogenated salicylanilides, or pharmaceutically acceptable salts or esters thereof, for use in the treatment of an infection in a subject caused by Clostridium bacteria, particularly a C. difficile infection. The halogenated salicylanilides are expected to be useful in the treatment of C. difficile associated diseases including C. difficile associated diarrhoea and C. difficile associated colitis.
-
公开(公告)号：US11324761B2
公开(公告)日：2022-05-10
申请号：US16899830
申请日：2020-06-12
发明人： Emilie Flora Aurore Delavenne , Daniel Jean Jacques Simon , Morten Otto Alexander Sommer , Rasmus Vendler Toft-Kehler
IPC分类号： A61K31/609 , A61K9/00 , A61K47/10 , A61K47/14 , A61K47/26 , A61K9/06 , A61P31/04 , A61P17/00
摘要： The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus, in particular Staphylococcus aureus, and Streptococcus, in particular Streptococcus pyogenes. Grain positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics.
-
3.发明授权公开(公告)号：US11292799B2
公开(公告)日：2022-04-05
申请号：US16772428
申请日：2018-12-14
IPC分类号： C07D495/04
摘要： The present invention relates to novel substituted azetidine dihydrothienopyrimidines with phosphodiesterase inhibitory activity, and to their use in therapy, and to pharmaceutical compositions comprising the compounds and to methods of treating diseases with the compounds (I).
-
公开(公告)号：US10857164B2
公开(公告)日：2020-12-08
申请号：US16589699
申请日：2019-10-01
IPC分类号： A61K31/609 , A61K31/612 , A61P31/04 , A61K45/06
摘要： The present invention relates to halogenated salicylanilides, or pharmaceutically acceptable salts or esters thereof, for use in the treatment of an infection in a subject caused by Clostridium bacteria, particularly a C. difficile infection. The halogenated salicylanilides are expected to be useful in the treatment of C. difficile associated diseases including C. difficile associated diarrhoea and C. difficile associated colitis.
-
公开(公告)号：US20200306270A1
公开(公告)日：2020-10-01
申请号：US16899821
申请日：2020-06-12
发明人： Emilie Flora Aurore DELAVENNE , Daniel Jean Jacques SIMON , Morten Otto Alexander SOMMER , Rasmus Vendler TOFT-KEHLER
IPC分类号： A61K31/609 , A61K9/00 , A61K47/10 , A61K47/14 , A61K47/26 , A61K9/06 , A61P31/04 , A61P17/00
摘要： The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus, in particular Staphylococcus aureus, and Streptococcus, in particular Streptococcus pyogenes. Grain positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics.
-
公开(公告)号：US12036312B2
公开(公告)日：2024-07-16
申请号：US16084741
申请日：2017-03-15
发明人： Morten Otto Alexander Sommer , Ping Li , Camilla Hasling Frandsen , Hanne Mørck Nielsen , Petra Alexandra Priemel , Thomas Rades
IPC分类号： A61K31/277 , A61K9/00 , A61K9/06 , A61K31/167 , A61K31/203 , A61K31/327 , A61K31/609 , A61K45/06 , A61K47/10 , A61K47/32 , A61K47/38 , A61P17/10 , A61P31/04
CPC分类号： A61K9/0014 , A61K9/06 , A61K31/167 , A61K31/203 , A61K31/327 , A61K31/609 , A61K45/06 , A61K47/10 , A61K47/32 , A61K47/38 , A61P17/10 , A61P31/04 , A61K31/609 , A61K2300/00 , A61K31/203 , A61K2300/00 , A61K31/327 , A61K2300/00
摘要： The present invention relates to non-aqueous topical compositions comprising a halogenated salicylanilide and the use of such compositions in the topical treatment or prevention of diseases and infections, particularly conditions caused by Gram-positive bacteria, for example the topical treatment or prevention of skin infections such as acne, atopic dermatitis and impetigo. Also disclosed are methods for preparing the gel composition.
-
公开(公告)号：US20230147683A1
公开(公告)日：2023-05-11
申请号：US17995079
申请日：2021-03-26
发明人： Morten SOMMER , Rasmus TOFT-KEHLER , Anne Katrine TOFT-KEHLER , Mads JELLINGSOE , Philippe ANDRES
IPC分类号： A61K31/609 , A61K47/10 , A61K47/22 , A61K31/167 , A61K9/00 , A61P31/14 , A61K47/32 , A61K47/40 , A61K47/20 , A61K47/00 , A61K9/08
CPC分类号： A61K31/609 , A61K47/10 , A61K47/22 , A61K31/167 , A61K9/0078 , A61P31/14 , A61K47/32 , A61K47/40 , A61K47/20 , A61K47/00 , A61K9/08 , A61K9/0043
摘要： Inhalable compositions comprising niclosamide, or a pharmaceutically acceptable salt thereof, and polyethylene glycol; aerosols of the compositions; and the pulmonary administrations for use in the treatment of viral infections, for example respiratory viral infections.
-
公开(公告)号：US20220323384A1
公开(公告)日：2022-10-13
申请号：US17723079
申请日：2022-04-18
发明人： Morten Otto Alexander Sommer , Rasmus Toft-Kehler , Anne Katrine Toft-Kehler , Günter Ditzinger , Mads Jellingsoe , Phillippe Andres , Matthias Knopp
摘要： The invention relates to a method of treating a viral infection caused by or associated with SARS-CoV-2 in a subject, the method comprising administering to the subject by inhalation intraorally and/or intranasally a therapeutically effective amount of a formulation comprising niclosamide, or a pharmaceutically acceptable salt thereof, and a cyclodextrin.
-
公开(公告)号：US11370799B2
公开(公告)日：2022-06-28
申请号：US16062760
申请日：2016-12-16
IPC分类号： C07D495/10
摘要： The present invention relates to novel methods for the preparation of 1,3-benzo-dioxole heterocyclic compounds and intermediates for the same. The compounds are useful as PDE4 inhibitors.
-
公开(公告)号：US20220162227A1
公开(公告)日：2022-05-26
申请号：US17539715
申请日：2021-12-01
IPC分类号： C07D495/10 , B01J21/16
摘要： The present invention relates to novel methods for the preparation of 1,3-benzodioxole heterocyclic compounds. The compounds are useful as PDE4 inhibitors.
-
-
-
-
-
-
-
-
-
搜索结果
41 条记录 (耗时 0.019 秒)
