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公开(公告)号：US20240269112A1
公开(公告)日：2024-08-15
申请号：US17917891
申请日：2021-04-09
IPC分类号： A61K31/4045 , A61K9/00 , A61K47/10 , A61P31/14
CPC分类号： A61K31/4045 , A61K9/0019 , A61K47/10 , A61P31/14
摘要： The present invention comprises an aqueous melatonin composition with unexpected long-term stability that allows high concentrations of this water-insoluble active substance for use thereof as an antiviral treatment.
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2.发明公开公开(公告)号：US20230414470A1
公开(公告)日：2023-12-28
申请号：US18463734
申请日：2023-09-08
IPC分类号： A61K8/49 , A61K8/35 , A61Q17/04 , A61Q19/08 , A61K9/00 , A61K31/122 , A61K31/4045
CPC分类号： A61K8/492 , A61K8/35 , A61K8/49 , A61Q17/04 , A61Q19/08 , A61K8/355 , A61K9/0014 , A61K31/122 , A61K31/4045 , A61K8/498 , A61K2800/78
摘要： The invention relates to a composition comprising melatonin, a metabolite or derivative thereof and coenzyme Q10 and to use thereof for the production of a pharmaceutical or cosmetic composition for the treatment of the skin, said composition potentiating the movement of both molecules into the mitochondrion and facilitating percutaneous absorption, in which both the melatonin and the CoQ10 can reach all of the strata of the skin.
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公开(公告)号：US20210106562A1
公开(公告)日：2021-04-15
申请号：US16498825
申请日：2018-04-02
发明人： Germaine ESCAMES ROSA , Darío ACUÑA CASTROVIEJO , Ana GUERRA-LIBRERO RITE , Beatriz Irene FERNÁNDEZ GIL , Javier FLORIDO RUIZ
IPC分类号： A61K31/4045 , A61K45/06 , A61P35/00 , A61K9/00
摘要： The present invention relates to the use of melatonin for the preparation of a pharmaceutical composition suitable for intratumoral administration for the treatment of tumors. This composition comprises high concentrations of melatonin, melatonin derivatives or metabolites, such that melatonin exerts an oxidizing effect, increasing the production of free radicals and activating cell death.
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4.发明申请COMPOSITION COMPRISING MELATONIN OR ITS DERIVATIVES WITH COENZYME Q10 AND USE THEREOF AGAINST AGEING OF THE SKIN 审中-公开包含MENATONIN或其衍生物与COENZYME Q10的组合物及其对皮肤老化的用途公开(公告)号：US20150306072A1
公开(公告)日：2015-10-29
申请号：US14648148
申请日：2013-11-26
IPC分类号： A61K31/4045 , A61K9/00 , A61Q19/08 , A61K8/35 , A61Q17/04 , A61K31/122 , A61K8/49
CPC分类号： A61K31/4045 , A61K8/35 , A61K8/355 , A61K8/49 , A61K8/492 , A61K9/0014 , A61K31/122 , A61K2800/78 , A61Q17/04 , A61Q19/08
摘要： The invention relates to a composition comprising melatonin, a metabolite or derivative thereof and coenzyme Q10 and to use thereof for the production of a pharmaceutical or cosmetic composition for the treatment of the skin, said composition potentiating the movement of both molecules into the mitochondrion and facilitating percutaneous absorption, in which both the melatonin and the CoQ10 can reach all of the strata of the skin.
摘要翻译： 本发明涉及包含褪黑激素，其代谢产物或其衍生物和辅酶Q10的组合物及其用于生产用于治疗皮肤的药物或化妆品组合物的用途，所述组合物增强两种分子进入线粒体的运动并促进 经皮吸收，其中褪黑素和CoQ10都可以到达皮肤的所有层。
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