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公开(公告)号：US20170321261A1
公开(公告)日：2017-11-09
申请号：US15512449
申请日：2015-09-18
发明人： María José SERRANO FERNÁNDEZ , Juan José DÍAZ MOCHÓN , Francisco GABRIEL ORTEGA , José Antonio LORENTE ACOSTA , José Luis GARCÍA PUCHE , Maria Paz RUIZ BLAS , Rosario María SÁNCHEZ MARTÍN
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6841 , C12Q1/6804 , C12Q1/6886 , C12Q2537/16 , C12Q2600/158 , C12Q2600/178 , G01N33/574
摘要： The present invention provides an in vitro method of detecting circulating tumour cells, circulating tumour cells of epithelial phenotype and circulating tumour cells of epithelial to mesenchymal transition (EMTs), in a biological sample using, as an indicator, expression levels of miRNA-21, and obtaining a result of the method by comparing the expression levels of said miRNA-21 with a negative control or with a positive control, wherein if the expression levels in the cells of the biological sample are over-expressed in comparison to a negative control is indicative of the presence of circulating tumour cells in said biological sample or wherein if the expression levels in the cells of the biological sample are expressed in an amount greater than ⅔ of the maximum expression achieved in a positive control is indicative of the presence of circulating tumour cells in said biological sample.
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公开(公告)号：US20230248847A1
公开(公告)日：2023-08-10
申请号：US17961445
申请日：2022-10-06
发明人： Rosario María SÁNCHEZ MARTÍN , Juan Antonio MARCHAL CORRALES , Juan José DÍAZ MOCHÓN , Victoria CANO CORTÉS , Saúl Abenhamar NAVARRO MARCHAL , Maria Paz RUIZ BLAS
IPC分类号： A61K49/00 , A61K47/69 , A61K47/64 , A61K47/60 , A61K31/704
CPC分类号： A61K49/0032 , A61K47/6933 , A61K47/64 , A61K47/60 , A61K31/704
摘要： The present invention relates to the field of medicine, particularly to functionalised nanoparticles (NP) for use in cancer therapy (treatment or diagnosis), to pharmaceutical compositions or nano devices comprising same, and also to a method for obtaining said functionalised nanoparticles. The nanoparticles described in the present invention can be used specifically to treat cancer efficiently, as same can selectively detect tumour cells.
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公开(公告)号：US20210162077A1
公开(公告)日：2021-06-03
申请号：US17265790
申请日：2019-04-12
发明人： Rosario María SÁNCHEZ MARTÍN , Juan Antonio MARCHAL CORRALES , Juan José DÍAZ MOCHÓN , Victoria CANO CORTÉS , Saúl Abenhamar NAVARRO MARCHAL , Maria Paz RUIZ BLAS
IPC分类号： A61K49/00 , A61K47/60 , A61K47/69 , A61K31/704 , A61K47/64
摘要： The present invention relates to the field of medicine, particularly to functionalised nanoparticles (NP) for use in cancer therapy (treatment or diagnosis), to pharmaceutical compositions or nano devices comprising same, and also to a method for obtaining said functionalised nanoparticles. The nanoparticles described in the present invention can be used specifically to treat cancer efficiently, as same can selectively detect tumour cells.
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