专利检索 ap:("UNIVERSIDADE DO PORTO" OR "FACULDADE DE FARMACIA DA UNIVERSIDADE DE LISBOA") AND inv:"Clara Isabel Ferreira Pereira" 第 1 页

1.

发明授权
Tryptophanol-derived oxazoloisoindolinones: small-molecule P53 activators 有权

公开(公告)号：US09732091B2

公开(公告)日：2017-08-15

申请号：US14901314

申请日：2014-06-26

申请人： UNIVERSIDADE DO PORTO , FACULDADE DE FARMACIA DA UNIVERSIDADE DE LISBOA

发明人： Lucilia Helena Ataide Saraiva , Maria Manuel Duque Vieira Marques Dos Santos , Nuno Alexandre Lousa Pereira , Clara Isabel Ferreira Pereira , Sara Gomes Moreira , Mariana Valencia Castanheira Ferreira Leao , Angelo Filipe Almeida Monteiro , Joana Oliveira Gama Soares

IPC分类号： C07D498/04 , A61K31/424 , A61K45/06

CPC分类号： C07D498/04 , A61K31/424 , A61K45/06 , A61K2300/00

摘要： The present application discloses novel family of Tryptophanol-Derived Oxazoloisoindolinones for use in the treatment of p53 associated conditions, such as cancer.These compounds are p53 activators and may be used in pharmaceutical compositions, alone or in combination with other chemotherapeutic agents.