公开(公告)号：US20190177798A1

公开(公告)日：2019-06-13

申请号：US16308990

申请日：2017-07-14

申请人： UNIVERSIDADE DO PORTO ,  IPATIMUP (INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO)

发明人： Berta Cecilia CAMPOS LIMA DE CARVALHO ,  Filipa ABREU GOMES DE CARVALHO ,  Carla Isabel GONCALVES DE OLIVEIRA ,  Patricia Joana MORAIS FERREIRA OLIVEIRA ,  Alexandra MATIAS PEREIRA DA CUNHA COELHO DE MACEDO

IPC分类号： C12Q1/6883

摘要： A new molecular based method for early screening of twin-to-twin transfusion syndrome (TTTS) of monochorionic twin pregnancies is provided in a rapid and non-invasive manner. Using real time quantitative PCR, this method is intended to quantify the expression of HBB, a new TTTS biomarker, in maternal plasma. In pregnant women with this condition, this biomarker is significantly reduced when compared to non-pregnant women, as well as pregnant women with both single and twin pregnancies without pathology. This method, if applied to all women with monochorionic twin pregnancies, will allow early screening of TTTS, benefiting both the mother and the fetuses, which can more quickly take advantage of an effective treatment with predictable improvement in fetuses' survival.

公开(公告)号：US12030891B2

公开(公告)日：2024-07-09

申请号：US17297347

申请日：2019-11-18

申请人： CIIMAR—CENTRO INTERDISCIPLINAR DE INVESTIGACAO MARINHA E AMBIENTAL ,  UNIVERSIDADE DO PORTO ,  FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA

发明人： Marta Ramos Pinto Correia Da Silva Carvalho Guerra ,  Madalena Maria De Magalhaes Pinto ,  Vitor Manuel De Oliveira E Vasconcelos ,  Joana Reis De Almeida ,  Elisabete Ribeiro Silva Geraldes ,  Maria Emilia Da Silva Pereira De Sousa

IPC分类号： C07D493/04 ,  A01N43/90 ,  C07D519/00 ,  C09D5/16

CPC分类号： C07D493/04 ,  A01N43/90 ,  C07D519/00 ,  C09D5/1625

摘要： Synthetic small molecules from an important class of heterocyclic derivatives and homologs and their use as antifouling agents for protection against marine biofouling. The antifouling compounds disclosed herein are environmentally friendly and are able to reduce marine biofouling without inducing toxic effects to target and non-target species. The claimed antifouling compounds also possess ability to be incorporated as antifouling additives in polymeric formulations. Thus, allowing its further application for the preparation of antifouling polymeric matrices, such as coatings, with no hazard effects for the environment.

公开(公告)号：US12017113B2

公开(公告)日：2024-06-25

申请号：US17413589

申请日：2019-12-12

申请人： UNIVERSIDADE DO PORTO

发明人： Maria Alice Da Costa Carvalhais ,  Manuel Renato Natal Jorge

IPC分类号： A63B23/20 ,  A61H19/00 ,  A61H21/00 ,  A63B21/06 ,  A63B21/065

CPC分类号： A63B23/20 ,  A61H19/44 ,  A61H21/00 ,  A63B21/0608 ,  A63B21/065

摘要： The present invention relates to a device for exercising the pelvic floor muscles in women, which comprises a main component (A), a secondary component (B) and a set of external weights (P).
Component (A) is directly related to pelvic floor muscle contraction exercise. Component (B) allows the evaluation and monitoring of contraction exercises by measuring the displacement of a rod on a graduated ruler. The set of weights (P), with different loads, allows it to impose resistance of different magnitudes on the muscle exercises to be performed, according to the user's needs and objectives.
Thus, this invention falls within the technical field of mechanical functioning devices, with application to the medical area, for the treatment and/or prevention of pathological situations related to the alteration of the muscular function of the pelvic floor region.

公开(公告)号：US20240191209A1

公开(公告)日：2024-06-13

申请号：US18484993

申请日：2023-10-11

申请人： Universidade do Porto - Reitoria

发明人： Paula Maria DAS NEVES FERREIRA DA SILVA ,  Pedro Jorge Fonseca MADUREIRA

IPC分类号： C12N9/02 ,  A01K67/0275 ,  A61K39/00 ,  A61K39/085 ,  A61K39/09 ,  A61K39/095 ,  A61K39/104 ,  A61K39/108 ,  C07K16/40

CPC分类号： C12N9/0008 ,  A01K67/0275 ,  A61K39/0258 ,  A61K39/0266 ,  A61K39/085 ,  A61K39/092 ,  A61K39/095 ,  A61K39/104 ,  C07K16/40 ,  C12Y102/01012 ,  A01K2217/00 ,  A61K2039/505 ,  A61K2039/55 ,  A61K2039/57 ,  C07K2317/76

摘要： The invention provides peptides derived from a ubiquitous protein, and nucleic acids encoding such peptides. The invention extends to various uses of these peptides and nucleic acids, for example, as antigens for use in vaccines per se and in the generation of antibodies for use in therapeutic drugs for the prevention, amelioration or treatment of infections caused by sepsis-inducing bacteria. The invention particularly benefits immunocompromised hosts such as neonates, babies, children, women of fertile age, pregnant women, foetuses, the elderly and diabetics.

公开(公告)号：US20230084724A1

公开(公告)日：2023-03-16

申请号：US17911435

申请日：2021-03-06

申请人： UNIVERSIDADE DO PORTO ,  BIOSCKIN, MOLECULAR & CELL THERAPIES S.A.

发明人： Ana MAURÍCIO ,  Ana BRANDÃO ,  Maria SIMÕES ,  Carla MEIRELES ,  Ana BARBOSA ,  Luís ATAíDE ,  Carla MENDONÇA

IPC分类号： A61L27/42 ,  C03C4/00 ,  C03C3/247 ,  A61L27/56

摘要： The present invention relates to a method for producing hydroxyapatite-bioglass macroporous material, to said materials, and to medical devices thereof.
The method comprises a step of preparation of an aqueous suspension of hydroxyapatite and bioglass with a porogenic agent, and subsequent sintering to achieve a macroporous biomaterial.
The macroporous structure of these materials enhances blood vessels and bone cells migration, allowing bone growth through the interior of the bone substitute, thereby increasing the rate of formation of new bone at the site of implantation. Therefore, these materials are advantageously used to produce medical devices, such as bone grafts that resemble the mineral phase of natural bone showing improved mechanical strength and osteoconductivity.
The biomaterials of the present invention are applicable in the medical area, in particular in bone regeneration and reparation techniques as bone grafts.

公开(公告)号：US11523607B2

公开(公告)日：2022-12-13

申请号：US16636057

申请日：2018-07-31

申请人： UNIVERSIDADE DO PORTO

发明人： Marco Aurélio Gouveia Alves ,  Carlos Pedro Fontes Oliveira ,  Mário Manuel Da Silva Leite De Sousa ,  Tito Miguel Boléo Teles De Jesus ,  Susana Paula Pinto De Almeida

IPC分类号： A01N1/02 ,  A61K35/48

摘要： The present invention refers to field of assisted reproductive technologies, in particular to a sperm storage media, and describes mTOR enhancers, preferably the mTOR activator MHY 1485, as supplement for storage media, said supplemented media increasing sperm motility and viability during short-term room temperature storage, while sustaining the metabolic rates, without changing its fertilization potential (capacitation) and DNA integrity.

公开(公告)号：US20220298098A1

公开(公告)日：2022-09-22

申请号：US17638398

申请日：2020-08-28

申请人： Ciimar - Centro Interdisciplinar De Investigaçäo Marinha E Ambiental ,  Universidad de Oviedo ,  Universidad De Almería ,  Fundacíon Privada Instituto De Salud Global de Barcelona (Isglobal) ,  Fotosintetica & Microbiologica Srl (F&M) ,  Universidade do Porto

发明人： Vitor Manuel DE OLIVEIRA E VASCONCELOS ,  Pedro Nuno COSTA LEÃO ,  Vítor Manuel CAPELA RAMOS ,  João Carlos PEREIRA MORAIS ,  Raquel CASTELO BRANCO ,  Flávio Luís DE OLIVEIRA ,  Mariana ALVES REIS ,  Sara María SOTO GONZÁLEZ ,  Yuly LÓPEZ CUBILLOS ,  Virginio CEPAS ,  Felipe LOMBÓ BRUGOS ,  Claudio J. VILLAR GRANJA ,  Ignacio Gutiérrez DEL RÍO MENÉNDEZ ,  Saúl REDONDO BLANCO ,  Fernando LÓPEZ ORTIZ ,  María José IGLESIAS VALDÉS-SOLÍS ,  Raquel María GONZÁLEZ SOENGAS ,  Liliana RODOLFI ,  Giacomo SAMPIETRO

IPC分类号： C07C69/63 ,  A61P31/04 ,  A61L27/54 ,  A61L29/16

摘要： The present disclosure relates to halogenated fatty acid lactylates, in particular to chlorinated fatty acid lactylates.
The halogenated fatty acid lactylates now disclosed have antimicrobial and/or antibiofilm activity towards healthcare associated microbial infections.

公开(公告)号：US20220151758A1

公开(公告)日：2022-05-19

申请号：US17598616

申请日：2020-03-30

申请人： UNIVERSIDADE DO PORTO ,  UNIVERSIDADE DO MINHO

发明人： Maria Ascensao FERREIRA DA SILVA LOPES ,  Diana Raquel DOS SANTOS MORAIS ,  Rui Jorge SOUSA COSTA DE MIRANDA GUEDES ,  Raul Manuel ESTEVES DE SOUSA FANGUEIRO ,  Juliana Patricia CORREIA DA CRUZ ,  Tiago DE MELO SILVA RAMOS PEREIRA ,  Joao Manuel DA COSTA FERREIRA TORRES

IPC分类号： A61F2/00 ,  A61F2/08 ,  A61L27/18 ,  A61L27/34 ,  A61L27/56 ,  A61L27/58

摘要： The present invention relates to a bio-functionalized fibrous structure with a core/shell architecture for partial or total repair of human tendons or ligaments. The architecture based on a core/shell system grants to the fibrous structure a specific physical and mechanical behaviour when it is repeatedly mechanically loaded, as happens with a native tendon or ligament in constant usage in the human body. The core is based on several sub-components, namely braided structures parallelly assembled, which are enclosed by a braided shell. Additionally, a selective bio-functionalization of the two parts of the core/shell structure can be applied in order to selectively improve or avoid the in vivo cell adhesion.

公开(公告)号：US20220113063A1

公开(公告)日：2022-04-14

申请号：US17265008

申请日：2019-08-01

申请人： UNIVERSIDADE DO PORTO ,  INEGI - INSTITUTO DE ENGENHARIA MECÂNICA E GESTÃO INDUSTRIAL

发明人： Szabolcs Varga ,  Armando Carlos Figueiredo Coelho DE OLIVEIRA ,  Fernando Gomes DE ALMEIDA ,  António Manuel Ferreira Mendes LOPES ,  João Pedro Barata Rocha Falcao CARNEIRO

IPC分类号： F25B1/06

摘要： A variable geometry ejector (300) for cooling applications is disclosed comprising a primary fluid chamber (302); a suction chamber (320) downstream the primary fluid chamber (302); a primary nozzle (310) arranged so as to stream a working fluid from the primary fluid chamber (302) to the suction chamber (320); and a tail member (325) arranged downstream the primary nozzle (310), wherein any of the primary nozzle (310) and the tail member (325) is movable in relation to the other.
The invention further discloses a system comprising the variable geometry ejector (300). The invention applies to cooling apparatus and systems industry.

公开(公告)号：US20210379122A1

公开(公告)日：2021-12-09

申请号：US17288383

申请日：2019-10-24

申请人： CIIMAR - CENTRO INTERDISCIPLINAR DE INVESTIGAÇÃO MARINHA E AMBIENTAL ,  UNIVERSIDADE DO PORTO

发明人： Claudia Alexandra DOS REIS SERRA ,  Paula Cristina ENES OLIVEIRA DA SILVA ,  Aires OLIVA TELES ,  Fernando TAVARES

IPC分类号： A61K35/742 ,  C12N1/20 ,  A23K50/80 ,  A23K10/18

摘要： The present disclosure relates to the isolation, identification and characterization of novel sporeforming probiotic strain(s) with NSPase (Non-Starch Polysaccharides-active hydrolases) activity isolated from fish gut microbiota, methods and uses thereof. The sporeforming probiotic strain(s) with NSPase activity now disclosed are able of producing carbohydrate-active enzymes (CAZymes) that hydrolyse non-starch polysaccharides (NSPs) and accesses their potential as probiotics (PRO) for use in particular in aquafeeds.