公开(公告)号：US20220151758A1

公开(公告)日：2022-05-19

申请号：US17598616

申请日：2020-03-30

申请人： UNIVERSIDADE DO PORTO ,  UNIVERSIDADE DO MINHO

发明人： Maria Ascensao FERREIRA DA SILVA LOPES ,  Diana Raquel DOS SANTOS MORAIS ,  Rui Jorge SOUSA COSTA DE MIRANDA GUEDES ,  Raul Manuel ESTEVES DE SOUSA FANGUEIRO ,  Juliana Patricia CORREIA DA CRUZ ,  Tiago DE MELO SILVA RAMOS PEREIRA ,  Joao Manuel DA COSTA FERREIRA TORRES

IPC分类号： A61F2/00 ,  A61F2/08 ,  A61L27/18 ,  A61L27/34 ,  A61L27/56 ,  A61L27/58

摘要： The present invention relates to a bio-functionalized fibrous structure with a core/shell architecture for partial or total repair of human tendons or ligaments. The architecture based on a core/shell system grants to the fibrous structure a specific physical and mechanical behaviour when it is repeatedly mechanically loaded, as happens with a native tendon or ligament in constant usage in the human body. The core is based on several sub-components, namely braided structures parallelly assembled, which are enclosed by a braided shell. Additionally, a selective bio-functionalization of the two parts of the core/shell structure can be applied in order to selectively improve or avoid the in vivo cell adhesion.