公开(公告)号：US20210061838A1

公开(公告)日：2021-03-04

申请号：US16848268

申请日：2020-04-14

Applicant: UNIVERSITÄT BASEL

Inventor： Beat Ernst ,  Ruben Herrendorff ,  Andreas Steck ,  Fan Yang

IPC: C07H15/207 ,  C07H15/203 ,  C08G69/10 ,  C08G69/48 ,  G01N33/68 ,  C08F2/00 ,  C08F120/36

Abstract: The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substituents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.

公开(公告)号：US20220185838A1

公开(公告)日：2022-06-16

申请号：US17538752

申请日：2021-11-30

Applicant: UNIVERSITÄT BASEL

Inventor： Beat Ernst ,  Ruben Herrendorff ,  Andreas Steck ,  Fan Yang

IPC: C07H15/207 ,  C07H15/203 ,  C08G69/10 ,  C08G69/48 ,  G01N33/68 ,  C08F2/00 ,  C08F120/36

Abstract: The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substituents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.

公开(公告)号：US11220523B2

公开(公告)日：2022-01-11

申请号：US16848268

申请日：2020-04-14

Applicant: UNIVERSITÄT BASEL

Inventor： Beat Ernst ,  Ruben Herrendorff ,  Andreas Steck ,  Fan Yang

IPC: C07H15/203 ,  C07H15/207 ,  C08G69/10 ,  C08G69/48 ,  G01N33/68 ,  C08F2/00 ,  C08F120/36

Abstract: The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substituents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.

公开(公告)号：US10662212B2

公开(公告)日：2020-05-26

申请号：US15977422

申请日：2018-05-11

Applicant: UNIVERSITÄT BASEL

Inventor： Beat Ernst ,  Ruben Herrendorff ,  Andreas Steck ,  Fan Yang

IPC: C07H15/207 ,  C07H15/203 ,  C08G69/10 ,  C08G69/48 ,  G01N33/68 ,  C08F2/00 ,  C08F120/36

Abstract: The invention relates to carbohydrate ligands presenting the minimal Human Natural Killer-1 (HNK-1) epitope that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and their use in diagnosis as well as for the treatment of anti-MAG neuropathy. In particular, the invention relates to disaccharides of formula (I) and (II) wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and to therapeutically acceptable polymers comprising a multitude of substitutents of formula (I) and/or formula (II), wherein Z is a bifunctional linker connecting the disaccharides to the polymer backbone.