公开(公告)号：US20240141269A1

公开(公告)日：2024-05-02

申请号：US18548738

申请日：2022-03-08

Applicant: UNIVERSITÄT BASEL

Inventor： Vesna PETKOVIC ,  Marijana SEKULIC

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M3/06

CPC classification number: C12M21/08 ,  C12M23/16 ,  C12M25/04 ,  C12M29/10

Abstract: A device is disclosed for modelling a blood labyrinth barrier of a human ear that includes a first fluid channel and a second fluid channel, and a membrane separating the first and second fluid channels. The membrane has a luminal side in the first fluid channel and an abluminal side in the second fluid channel, endothelial cells attached to the luminal side of the membrane, pericytes attached to the abluminal side of the membrane, and perivascular macrophage-type melanocytes arranged in the second fluid channel. A method of preparing such device is also disclosed. As well, a device with two fluid channels and a membrane as described above is disclosed, wherein the endothelial cells, pericytes and perivascular macrophage-type melanocytes are arranged in two fluid containers.