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    SINGLE-CHAIN TNF LIGAND FAMILY MOLECULES AND FUSION PROTEINS AND DERIVATIVES THEREOF
    1.
    发明申请
    SINGLE-CHAIN TNF LIGAND FAMILY MOLECULES AND FUSION PROTEINS AND DERIVATIVES THEREOF 审中-公开

    公开(公告)号：US20180094059A1

    公开(公告)日：2018-04-05

    申请号：US15558372

    申请日：2016-03-18

    Applicant: UNIVERSITÄT STUTTGART ,  BIONTECH AG

    Inventor： Ugur SAHIN ,  Roland KONTERMANN ,  Klaus PFIZENMAIER ,  Martin SIEGEMUND ,  Meike HUTT ,  Oliver SEIFERT

    IPC: C07K16/28 ,  C07K16/32 ,  C07K14/705

    CPC classification number: C07K16/2863 ,  C07K14/70575 ,  C07K16/32 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/91

    Abstract: The present invention relates to a polypeptide comprising a component A with at least three tumor necrosis factor (TNF) homology domains of TNF-ligand family members (THD) in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof, and a component B comprising a dimerization domain. Further, the present invention relates to a polypeptide comprising at least three THDs in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof. Further, the invention relates to a nucleic acid comprising said polypeptides, a vector comprising said nucleic acid and a pharmaceutical composition comprising said polypeptides, or said nucleic acids or said vector. Further, the present invention relates to said polypeptides, said nucleic acid or said vector for the use as a medicament or for the use in the diagnosis, prophylaxis or treatment of hyperproliferative disorders and inflammatory disorders.

    BINDING MODULES COMPRISING MODIFIED EHD2 DOMAINS
    4.
    发明申请
    BINDING MODULES COMPRISING MODIFIED EHD2 DOMAINS 有权

    公开(公告)号：US20220372147A1

    公开(公告)日：2022-11-24

    申请号：US17762463

    申请日：2020-09-25

    Applicant: UNIVERSITÄT STUTTGART

    Inventor： Roland KONTERMANN ,  Oliver SEIFERT

    IPC: C07K16/28 ,  C07K16/46

    Abstract: The present invention relates to binding molecules comprising two polypeptide chains, wherein the peptide chains comprise modified EHD2 domains allowing heterodimerization only, thereby preventing homodimers, nucleic acids encoding such binding molecules and uses of such binding molecules or nucleic acids encoding such binding molecules in therapy.

    TRIVALENT BINDING MOLECULES
    6.
    发明申请
    TRIVALENT BINDING MOLECULES 有权

    公开(公告)号：US20220396635A1

    公开(公告)日：2022-12-15

    申请号：US17762626

    申请日：2020-09-25

    Applicant: UNIVERSITÄT STUTTGART

    Inventor： Roland KONTERMANN ,  Oliver SEIFERT ,  Nadine ASCHMONEIT

    IPC: C07K16/32 ,  C07K16/28

    Abstract: The present invention relates to a trivalent binding molecule comprising a first polypeptide comprising two binding domains and a second polypeptide comprising a third binding domain. The present invention further relates to the trivalent binding molecule for use in medicine and in particular in the prophylaxis, treatment or diagnosis of a disorder or disease.

    HETERODIMERIZING IG DOMAINS
    8.
    发明申请
    HETERODIMERIZING IG DOMAINS 审中-公开

    公开(公告)号：US20200172619A1

    公开(公告)日：2020-06-04

    申请号：US16615536

    申请日：2018-06-01

    Applicant: UNIVERSITÄT STUTTGART

    Inventor： Fabian RICHTER ,  Oliver SEIFERT ,  Roland KONTERMANN

    IPC: C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40

    Abstract: The present invention provides a protein complex comprising heterodimerizing regions HRI and HRII, each comprised of antiparallel β-strands and intervening regions wherein HRI and HRII are each interspersed fusion proteins of two human constant regions of an immunoglobulin or immunoglobulin-like proteins. The present invention also provides nucleic acid molecules comprising a sequence encoding said protein complexes and vectors comprising the nucleic acid. The present invention also provides the protein complex, the nucleic acid and the vector for use as a medicament. The present invention further provides a method of determining the amino acid sequence of HRI and/or of the amino acid sequence of HRII. The present invention also provides a method of producing amino acid chains of HRI and/or amino acid chains of HRII. The present invention further provides the protein complex for use in the N prophylaxis, treatment or diagnosis of a disorder or a disease.

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