公开(公告)号：US12144299B2

公开(公告)日：2024-11-19

申请号：US15780636

申请日：2016-11-30

Applicant: UNIVERSITAT BASEL

Inventor： Etienne Bucher ,  Michael Thieme

IPC: A01H3/04 ,  A01H1/06 ,  C12N15/01 ,  C12N15/82

Abstract: A method for the mobilization of a transposable element is provided. The method comprises the steps of a) providing an inhibitor of DNA methylation, and/or an inhibitor of transcription, and b) contacting the inhibitor(s) with a cell comprising inactivated transposable elements, yielding a cell with mobilized transposable elements. In a second aspect of the invention a method for increasing the genetic and/or epigenetic variation in a plurality of eukaryotic organisms is provided. The method comprises the steps of i. providing an inhibitor of DNA methylation and/or an inhibitor of transcription, ii. contacting the organism with the inhibitor(s) and iii. propagating the organism.