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1.发明授权公开(公告)号：US12144299B2
公开(公告)日：2024-11-19
申请号：US15780636
申请日：2016-11-30
Applicant: UNIVERSITAT BASEL
Inventor： Etienne Bucher , Michael Thieme
Abstract: A method for the mobilization of a transposable element is provided. The method comprises the steps of a) providing an inhibitor of DNA methylation, and/or an inhibitor of transcription, and b) contacting the inhibitor(s) with a cell comprising inactivated transposable elements, yielding a cell with mobilized transposable elements. In a second aspect of the invention a method for increasing the genetic and/or epigenetic variation in a plurality of eukaryotic organisms is provided. The method comprises the steps of i. providing an inhibitor of DNA methylation and/or an inhibitor of transcription, ii. contacting the organism with the inhibitor(s) and iii. propagating the organism.
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公开(公告)号：US20190250078A1
公开(公告)日：2019-08-15
申请号：US16342529
申请日：2017-10-17
Applicant: UNIVERSITAT BASEL
Inventor： Thomas BRAUN , Stefan ARNOLD , Henning STAHLBERG
CPC classification number: G01N1/2813 , G01N1/42 , G01N1/44
Abstract: Method for preparing a sample, wherein the sample is provided as a thin film on a support structure; the temperature of the support structure is adjusted to a value above the dew point temperature of the environment to decrease the film thickness, light is directed at the support structure, an intensity value of the transmitted light is measured, and the support structure is automatically inserted into a liquid cryogen dependent on the measured intensity value. The application further relates to a system comprising a support structure, a temperature-controlled stage for keeping the support structure at a pre-defined temperature, a transfer mechanism for moving the support structure into a container containing a liquid cryogen, a light source, a photodetector for measuring an intensity value of the transmitted light, and a control device for triggering the transfer mechanism dependent on the measured intensity value.
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公开(公告)号：US20190169263A1
公开(公告)日：2019-06-06
申请号：US16323902
申请日：2017-08-09
Applicant: UNIVERSITAT ZURICH , UNIVERSITAT BASEL
Inventor： Osiris MARROQUIN BELAUNZARAN , Christoph RENNER
Abstract: The invention relates to MHC-Ia open conformers as immunomodulatory agents, particularly in the treatment or prevention of cancer. The open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-heavy chain from the MHC-Ia molecules. The open conformer further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the MHC-Ia open conformers and immune checkpoint inhibitors.Furthermore, the invention relates to the use of MHC-Ia open conformers as immunomodulators, particularly in diseases where the interaction to diverse immunoregulatory receptors such as KIR3DL1, KIR3DL2, KIR3DL3, LILRB1, LILRB2, and PTPRJ modulates an immune response, and in diseases were the negative modulation of Tregs is a therapeutic strategy, e.g. infectious diseases.
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公开(公告)号：US20230321186A1
公开(公告)日：2023-10-12
申请号：US18189190
申请日：2023-03-23
Applicant: Massachusetts Institute of Technology , Universitat Basel
Inventor： Katharina Ribbeck , Julie Sant'Anna Takagi , Rachel Hevey
CPC classification number: A61K38/1735 , A61P31/10 , A61K47/549
Abstract: The disclosure provides, in various embodiments, methods of treating fungal infections in subjects in need thereof, methods of attenuating virulence of fungi (e.g., in subjects in need thereof), and methods of inhibiting formation of fungal biofilms on surfaces (e.g., living or inert surfaces) with mucin glycans, tautomer, stereoisomer and/or pharmaceutically acceptable salts thereof. The disclosure further provides, in various embodiments, mucin glycan compositions, such as synthetic mucin glycans and defined mucin glycan compositions.
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公开(公告)号：US11369660B2
公开(公告)日：2022-06-28
申请号：US16083508
申请日：2017-03-07
Applicant: UNIVERSITAT ZURICH , UNIVERSITAT BASEL
Inventor： Osiris Marroquin Belaunzaran , Ulf Petrausch , Christoph Renner
Abstract: The invention relates to a HLA-B57 open conformer or a HLA-B57 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B57 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B57 Fc open conformer and immune checkpoint inhibitors and/or checkpoint agonist agents.
Furthermore, the invention relates to the use of HLA-B57 open conformer as an immunomodulator, particularly in diseases where modulation of diverse immune cell components (e.g. cytotoxic CD8+ T cells, Tregs) is a therapeutic strategy, e.g. infectious diseases.-
Patent Agency Ranking
6.发明申请公开(公告)号：US20210045690A1
公开(公告)日：2021-02-18
申请号：US16976917
申请日：2019-03-01
Applicant: Universitat Basel Vizerektorat Forschung
Inventor： Bekim OSMANI , Tino TOPPER , Bert MUELLER , Per Magnus KRISTIANSEN , Helmut SCHIFT
Abstract: For improving the electroactivity and long-term stability of a neural interface, a novel neural probe (1) is proposed that is formed from a fiber (6), preferably by thermal imprinting, and wherein a polymer thin film (5) is employed for carrying a conducting thin film to be used as a recording or stimulation electrode (4). Due to this specific choice of materials and design, the electrode (4) is rendered compliant with respect to the fiber (6) on a nanometer to micrometer scale and offers a surface that is tailor-made for adhering to nervous tissue.
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公开(公告)号：US09971000B2
公开(公告)日：2018-05-15
申请号：US14387256
申请日：2013-03-23
Applicant: UNIVERSITAT BASEL
Inventor： Pascal Bohi , Max F. Riedel , Theodor W. Hansch , Philipp Treutlein
CPC classification number: G01R33/323 , G01R33/10 , G01R33/1284 , G01R33/48
Abstract: A device for sensing a microwave magnetic field polarization component (B−, Bπ, B+) of a microwave relative to a static magnetic field B0, comprising a preparation means to prepare atomic vapor (10) comprising thermal atoms in a first hyperfine state, particularly a dark state to applied laser light, which first hyperfine state is split from other hyperfine state due to zero-field hyperfine splitting and/or due to a static magnetic field (B0) generated by preparation means, at least one cell enclosing the thermal atoms (10), the microwave is adapted to drive Rabi oscillations of thermal atoms between first hyperfine state and second hyperfine state, Rabi frequency of Rabi oscillations being proportional to magnetic field polarization component (B−, Bπ, B+) of the microwave, and imaging means to capture state image of plurality of atoms representing spatial atomic density distribution (Ne) as a function of the Rabi frequency (Ωi(r)) of Rabi oscillations.
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公开(公告)号：US20170299570A1
公开(公告)日：2017-10-19
申请号：US15516404
申请日：2015-10-05
Applicant: UNIVERSITAT BASEL
Inventor： Marko LOPARIC , Marija PLODINEC , Ellen OBERMANN , Christian RAEZ
IPC: G01N33/483 , G01Q60/36
CPC classification number: G01N33/4833 , G01N2800/56 , G01N2800/7028 , G01Q60/366
Abstract: The invention relates to a method for staging metastatic potential of a primary tumour sample or related lymph node by nanomechanical measurement and/or for determing the reoccurrence or incidence potential.
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公开(公告)号：US20150048824A1
公开(公告)日：2015-02-19
申请号：US14387256
申请日：2013-03-23
Applicant: UNIVERSITAT BASEL
Inventor： Pascal Bohi , Max F. Riedel , Theodor W. Hansch , Philipp Treutlein
CPC classification number: G01R33/323 , G01R33/10 , G01R33/1284 , G01R33/48
Abstract: The invention relates to a device for sensing a microwave magnetic field polarization component (B−, Bπ, B+,) of a microwave relative to a static magnetic field B0, comprising: a preparation means being designed to prepare an atomic vapor (10) comprising a plurality of thermal atoms in a first hyperfine state, particularly a dark state to applied laser light, which first hyperfine state is split from at least one other hyperfine state due to the zero-field hyperfine splitting and/or due to a static magnetic field (B0) generated by said preparation means, at least one cell (1) enclosing said plurality of thermal atoms (10), wherein said microwave is adapted to drive Rabi oscillations of said plurality of thermal atoms between said first hyperfine state and a second hyperfine state, the Rabi frequency of said Rabi oscillations being proportional to said magnetic field polarization component (B−, Bπ, B+) of said microwave, and an imaging means being designed to capture a state image of said plurality of atoms representing the spatial atomic density distribution (Ne) being a function of the Rabi frequency (Ωi(r)) of said Rabi oscillations. Further, the invention relates to a method for sensing a microwave field.
Abstract translation: 本发明涉及一种用于感测微波相对于静态磁场B0的微波磁场偏振分量（B-，B＆Pgr，B +））的装置，包括：制备装置，其被设计成制备原子蒸气（10） 包括第一超精细状态的多个热原子，特别是施加激光的暗状态，由于零场超精细分裂和/或由于静态磁场，第一超精细状态从至少一个其他超精细状态分裂 由所述制备装置产生的场（B0），包围所述多个热原子（10）的至少一个电池（1），其中所述微波适于驱动所述多个热原子的Rabi振荡在所述第一超精细状态和第二超精细状态之间 所述超精细状态，所述Rabi振荡的Rabi频率与所述微波的所述磁场偏振分量（B-，B＆Pgr，B +）成比例，并且成像装置被设计成捕获状态 代表所述Rabi振荡的Rabi频率（＆OHgr; i（r））的函数的表示空间原子密度分布（Ne）的所述多个原子的图像。 此外，本发明涉及一种用于感测微波场的方法。
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公开(公告)号：US11982580B2
公开(公告)日：2024-05-14
申请号：US16976908
申请日：2019-03-01
Applicant: Universitat Basel Vizerektorat Forschung
Inventor： Tino Topper , Bekim Osmani , Bert Mueller
IPC: G01L1/14 , H10N30/098 , H10N30/20 , H10N30/857
CPC classification number: G01L1/146 , H10N30/098 , H10N30/206 , H10N30/857
Abstract: For improving the sensitivity, lifetime and energy consumption of a dielectric elastomer transducer (1) to be used as a sensor, it is suggested that a dielectric layer (3) enclosed by two electrodes (2) of the transducer (1) includes a nanoscale volume of a fluid (15) such that the dielectric layer (3) is rendered compressible and/or displaceable out of a volume enclosed by the two electrodes (2). The advantage of such a design is that, although the dielectric layer (3) and possible buffer layers (4) separating the electrodes (2) from the dielectric layer (3) may all have thicknesses in the order of a few μm or even in the sub-μm range, the transducer (1) is rendered highly compliant due to the movability of the fluid (15). In consequence, a large nominal capacitance of the transducer (1) as well as a large relative capacitance change (up to twenty times that of the nominal capacitance) can be achieved in conjunction with a very high sensitivity.
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