公开(公告)号：US20190167600A1

公开(公告)日：2019-06-06

申请号：US16322312

申请日：2017-08-03

申请人： UNIVERSITY OF BATH

发明人： Asel Sartbaeva ,  Stephen Wells

IPC分类号： A61K9/51 ,  A61K39/39 ,  A61K9/20 ,  A61K9/00

摘要： The present invention provides a way to capture a biomolecule such as a protein in one or more layers of covalently bonded amorphous silica, forming a cage or shell which preserves the shape of the protein and prevents denaturation caused by heat and/or aging and/or non-physiological conditions, through unfolding and loss of secondary and/or higher order structure.

公开(公告)号：US10881620B2

公开(公告)日：2021-01-05

申请号：US16322312

申请日：2017-08-03

申请人： UNIVERSITY OF BATH

发明人： Asel Sartbaeva ,  Stephen Wells

IPC分类号： A61K9/51 ,  A61K9/50 ,  A61K39/00 ,  B82Y5/00 ,  A61K39/08 ,  A61K9/00 ,  A61K9/20 ,  A61K39/39

摘要： The present invention provides a way to capture a biomolecule such as a protein in one or more layers of covalently bonded amorphous silica, forming a cage or shell which preserves the shape of the protein and prevents denaturation caused by heat and/or aging and/or non-physiological conditions, through unfolding and loss of secondary and/or higher order structure.