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    METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION
    1.
    发明公开
    METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION 审中-公开

    公开(公告)号：US20240207212A1

    公开(公告)日：2024-06-27

    申请号：US18517596

    申请日：2023-11-22

    申请人： UNIVERSITY OF MASSACHUSETTS ,  UNIVERSITY OF BATH

    发明人： Randall Mrsny ,  Beth McCormick ,  Roland Ellwood Dolle

    IPC分类号： A61K31/195 ,  A61K47/59 ,  A61K47/60 ,  A61K47/61

    CPC分类号： A61K31/195 ,  A61K47/593 ,  A61K47/60 ,  A61K47/61

    摘要： Disclosed herein are methods and compositions for treating neutrophil-mediated inflammation by targeting, in any combination, the pro-inflammatory MRP2/HXA3 pathway and/or the anti-inflammatory P-gp/endocannabinoid pathway and/or the anti-inflammatory MRP 1/L-AMEND pathway, comprising administering to the subject a therapeutically effective amount of (a) one or more first compound that inhibits the activity and/or level of one or more of multidrug resistance protein 2 (MRP2) and hepoxilin A3 (HXA3) synthase, and/or (b) one or more second compound that increases the level and/or activity of one or more N-acylethanolamines (NAEs), and/or (c) one or more third compound that increases the level and/or activity of multidrug resistance protein 1 (MRP1), wherein the therapeutic amount of the first, second, and third compounds reduces migration of neutrophils into the target tissue.

    Methods and compositions for treating inflammation
    2.
    发明授权
    Methods and compositions for treating inflammation 有权

    公开(公告)号：US11865093B2

    公开(公告)日：2024-01-09

    申请号：US16631023

    申请日：2018-07-13

    申请人： UNIVERSITY OF MASSACHUSETTS ,  UNIVERSITY OF BATH

    发明人： Randall Mrsny ,  Beth McCormick ,  Roland Ellwood Dolle

    IPC分类号： A61K31/195 ,  A61K47/59 ,  A61K47/61 ,  A61K47/60

    CPC分类号： A61K31/195 ,  A61K47/593 ,  A61K47/60 ,  A61K47/61

    摘要： Disclosed herein are methods and compositions for treating neutrophil-mediated inflammation by targeting, in any combination, the pro-inflammatory MRP2/HXA3 pathway and/or the anti-inflammatory P-gp/endocannabinoid pathway and/or the anti-inflammatory MRP 1/L-AMEND pathway, comprising administering to the subject a therapeutically effective amount of (a) one or more first compound that inhibits the activity and/or level of one or more of multidrug resistance protein 2 (MRP2) and hepoxilin A3 (HXA3) synthase, and/or (b) one or more second compound that increases the level and/or activity of one or more N-acylethanolamines (NAEs), and/or (c) one or more third compound that increases the level and/or activity of multidrug resistance protein 1 (MRP1), wherein the therapeutic amount of the first, second, and third compounds reduces migration of neutrophils into the target tissue.

    BIOMOLECULE PRESERVATION
    6.
    发明申请
    BIOMOLECULE PRESERVATION 审中-公开

    公开(公告)号：US20190167600A1

    公开(公告)日：2019-06-06

    申请号：US16322312

    申请日：2017-08-03

    申请人： UNIVERSITY OF BATH

    发明人： Asel Sartbaeva ,  Stephen Wells

    IPC分类号： A61K9/51 ,  A61K39/39 ,  A61K9/20 ,  A61K9/00

    摘要： The present invention provides a way to capture a biomolecule such as a protein in one or more layers of covalently bonded amorphous silica, forming a cage or shell which preserves the shape of the protein and prevents denaturation caused by heat and/or aging and/or non-physiological conditions, through unfolding and loss of secondary and/or higher order structure.