公开(公告)号：US20220204452A1

公开(公告)日：2022-06-30

申请号：US17601151

申请日：2020-04-03

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Debopam CHAKRABARTI ,  YU YUAN ,  Guang HUANG ,  Claribel Murillo SOLANO

IPC: C07D215/46 ,  A61P33/06 ,  C07D401/04 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

Abstract: Antimalarial compounds of the formula: in which n is 1 or 2; X is C or N; R1 is a moiety comprising a secondary amine and a tertiary amine joined by a C2 to C4 alkyl chain; and R2 is CF3, F, or H, or an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof. Pharmaceutical compounds including the antimalarial compounds. Methods of treating or preventing malaria comprising administering an effective amount of the antimalarial compounds.

公开(公告)号：US20220144894A1

公开(公告)日：2022-05-12

申请号：US17582787

申请日：2022-01-24

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA ,  UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION , INC.

Inventor： Debopam CHAKRABARTI ,  Robert H. CICHEWICZ ,  Shengxin CAI ,  Jin Woo LEE ,  Jennifer E. COLLINS

IPC: C07K7/08 ,  A61P33/06

Abstract: Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.

公开(公告)号：US20190077768A1

公开(公告)日：2019-03-14

申请号：US16126645

申请日：2018-09-10

Applicant: University of Central Florida Research Foundation, Inc.

Inventor： Debopam CHAKRABARTI ,  Ratna CHAKRABARTI

IPC: C07D239/38 ,  A61P33/06 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.