公开(公告)号：US20190262105A1

公开(公告)日：2019-08-29

申请号：US16286005

申请日：2019-02-26

申请人： UNIVERSITY OF CENTRAL OKLAHOMA

发明人： Vagan TAPALTSYAN ,  Morshed KHANDAKER ,  Shahram RIAHINEZHAD ,  Rami Mohanad Mahdi ALKHALEELI ,  Niyaf Nidhal Kadhem ALKADHEM

IPC分类号： A61C8/02 ,  A61C8/00 ,  A61C13/00 ,  A61K6/097 ,  A61K6/087

摘要： The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturation—BMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.

公开(公告)号：US20220000588A1

公开(公告)日：2022-01-06

申请号：US17476182

申请日：2021-09-15

申请人： UNIVERSITY OF CENTRAL OKLAHOMA

发明人： Vagan TAPALTSYAN ,  Morshed KHANDAKER ,  Shahram RIAHINEZHAD ,  Rami Mohanad Mahdi ALKHALEELI ,  Niyaf Nidhal Kadhem ALKADHEM

IPC分类号： A61C8/02 ,  A61K6/891 ,  A61K6/898 ,  A61C13/00 ,  A61C8/00

摘要： The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturation—BMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.

公开(公告)号：US20210338383A1

公开(公告)日：2021-11-04

申请号：US17374700

申请日：2021-07-13

申请人： UNIVERSITY OF CENTRAL OKLAHOMA

发明人： Vagan TAPALTSYAN ,  Morshed KHANDAKER ,  Shahram RIAHINEZHAD ,  Rami Mohanad Mahdi ALKHALEELI ,  Niyaf Nidhal Kadhem ALKADHEM

IPC分类号： A61C8/02 ,  A61C8/00 ,  A61C13/00 ,  A61K6/891 ,  A61K6/898

摘要： The present invention enables modification of an intraosseous implant device that is not only biologically non-inert, but can stimulate bone and vascular growth; decrease localized inflammation; and fight local infections. The method of the present invention provides a fiber with any of the following modifications: (1) Nanofiber with PDGF, (2) Nanofiber with PDGF+BMP2, and (3) Nanofiber with BMP2 and Ag. Nanofiber can be modified with other growth factors that have been shown to improve bone growth and maturation—BMP and PDGF being the most common. Nanofiber can be applied on the surface of the implant in several ways. First, a spiral micro-notching can be applied on the implant in the same direction as the threads with the nanofibers embedded into the notches. Second, the entire surface of the implant may be coated with a mesh of nanofibers. Third, it can be a combination of both embedding and notching.