公开(公告)号：US11219606B2

公开(公告)日：2022-01-11

申请号：US15028496

申请日：2014-10-09

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Anuj Chauhan ,  Robert A. Damitz

IPC: A61K31/05 ,  A61K9/107 ,  A61K47/44 ,  A61K9/00 ,  A61K47/14 ,  A61K47/10

Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.

公开(公告)号：US20220079890A1

公开(公告)日：2022-03-17

申请号：US17456956

申请日：2021-11-30

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Anuj Chauhan ,  Robert A. Damitz

IPC: A61K31/05 ,  A61K9/107 ,  A61K47/44 ,  A61K9/00 ,  A61K47/14 ,  A61K47/10

Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.

公开(公告)号：US11963936B2

公开(公告)日：2024-04-23

申请号：US17456956

申请日：2021-11-30

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Anuj Chauhan ,  Robert A. Damitz

IPC: A61K31/05 ,  A61K9/00 ,  A61K9/107 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

CPC classification number: A61K31/05 ,  A61K9/0019 ,  A61K9/107 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.