公开(公告)号：US11998481B2

公开(公告)日：2024-06-04

申请号：US17258767

申请日：2019-08-02

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Keith G. Christopher

IPC: A61F9/00 ,  A61N1/04 ,  A61N1/30

CPC classification number: A61F9/0017 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/303

Abstract: In one aspect, the disclosure relates to drug delivery devices for the ionophoretic delivery of a therapeutic agent(s) to the eye. In some aspects, the disclosed ionophoretic ocular delivery device is configured for delivery of a therapeutic agent to the anterior portion of the eye. In various aspects, the present disclosure provides methods for treatment of an ophthalmological disorder, disease, or clinical condition by delivering a therapeutic agent(s) to the eye using a disclosed ionophoretic ocular delivery device. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11963936B2

公开(公告)日：2024-04-23

申请号：US17456956

申请日：2021-11-30

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Anuj Chauhan ,  Robert A. Damitz

IPC: A61K31/05 ,  A61K9/00 ,  A61K9/107 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

CPC classification number: A61K31/05 ,  A61K9/0019 ,  A61K9/107 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.

公开(公告)号：US11771665B2

公开(公告)日：2023-10-03

申请号：US17824235

申请日：2022-05-25

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon

IPC: A61K31/145 ,  A61K47/42 ,  A45C11/00 ,  A61K9/00 ,  A61F9/00 ,  A61K47/22

CPC classification number: A61K31/145 ,  A45C11/005 ,  A61F9/0008 ,  A61K9/0048 ,  A61K47/22 ,  A61K47/42

Abstract: Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.

公开(公告)号：US20220134694A1

公开(公告)日：2022-05-05

申请号：US17647859

申请日：2022-01-13

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: B29D11/00 ,  G02C7/04

Abstract: In general, the disclosure relates to methods and compositions for preparing colorants useful for preparing pigmented hydrogels. The disclosure further relates to pigmented hydrogels comprising the disclosed colorants. In some instances, the colorant is an alcohol extract of an agro-material, such as turmeric, paprika, spinach, and/or pokorny woad or the colorants comprise one or more of: a carotenoid, chlorophyll-a, chlorophyll-b, a curcumoid, or indigorubin. Alternatively, the colorant can be carbon black. The disclosure further relates to contact lenses comprising the disclosed pigmented hydrogels.

公开(公告)号：US09594188B2

公开(公告)日：2017-03-14

申请号：US14296899

申请日：2014-06-05

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Anuj Chauhan ,  Hyun-Jung Jung ,  Samuel B. Gause

IPC: G02B1/04 ,  B29D11/00 ,  B82Y30/00 ,  B82Y20/00

CPC classification number: G02C7/108 ,  B29D11/00038 ,  B29D11/00346 ,  B29D11/00634 ,  B29K2083/00 ,  B82Y20/00 ,  B82Y30/00 ,  G02B1/043 ,  G02C7/049 ,  Y10S977/834 ,  Y10T428/2982 ,  C08L101/14 ,  C08L33/08 ,  C08L33/26 ,  C08L33/10

Abstract: UV absorbing appliances, such as contact lenses, are prepared by including at least one UV absorbing compound in the appliances. UV absorbing compounds can be water insoluble and/or reside in UV absorbing nanoparticles having a mean diameter less than 10 nm. The UV absorbing nanoparticles incorporate into an appliance by polymerizing a monomer mixture containing the UV absorbing nanoparticles to form an appliance comprising the UV absorbing nanoparticles. The UV absorbing compounds or the UV absorbing nanoparticles incorporate into an appliance by placing the appliance in a solution of the UV absorbing compound or a dispersion of the UV absorbing nanoparticles in a non-aqueous solvent that swells the appliance. The UV absorbing compound or the UV absorbing nanoparticles infuse into the swollen appliance and are retained within the appliance upon removal of the non-aqueous solvent.

Abstract translation: 通过在器具中包含至少一种UV吸收化合物来制备紫外线吸收器具，例如隐形眼镜。 UV吸收化合物可以是水不溶性的和/或驻留在平均直径小于10nm的UV吸收纳米颗粒中。 UV吸收纳米颗粒通过聚合含有UV吸收纳米颗粒的单体混合物结合到器具中以形成包含UV吸收纳米颗粒的器具。 UV吸收化合物或UV吸收纳米颗粒通过将该器具放置在UV吸收化合物或UV吸收纳米颗粒的分散体的溶液中而溶解在器具中，使其溶解在使水分膨胀的非水溶剂中。 UV吸收化合物或UV吸收纳米粒子注入溶胀的器具中，并且在除去非水溶剂后保留在器具内。

公开(公告)号：US20240261139A1

公开(公告)日：2024-08-08

申请号：US18640036

申请日：2024-04-19

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Keith G. Christopher

IPC: A61F9/00 ,  A61N1/04 ,  A61N1/30

CPC classification number: A61F9/0017 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/303

Abstract: In one aspect, the disclosure relates to drug delivery devices for the ionophoretic delivery of a therapeutic agent(s) to the eye. In some aspects, the disclosed ionophoretic ocular delivery device is configured for delivery of a therapeutic agent to the anterior portion of the eye. In various aspects, the present disclosure provides methods for treatment of an ophthalmological disorder, disease, or clinical condition by delivering a therapeutic agent(s) to the eye using a disclosed ionophoretic ocular delivery device. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11219606B2

公开(公告)日：2022-01-11

申请号：US15028496

申请日：2014-10-09

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Anuj Chauhan ,  Robert A. Damitz

IPC: A61K31/05 ,  A61K9/107 ,  A61K47/44 ,  A61K9/00 ,  A61K47/14 ,  A61K47/10

Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.

公开(公告)号：US20220000662A1

公开(公告)日：2022-01-06

申请号：US17337069

申请日：2021-06-02

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Kuan-Hui Hsu

IPC: A61F9/00 ,  A61J1/05 ,  A61J1/14 ,  A61K9/00 ,  A61K31/382 ,  A61K31/5377 ,  A61K31/5575 ,  A61K31/573 ,  A61K47/18 ,  B01D15/00 ,  B01J20/26 ,  C08J9/28

Abstract: A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.

公开(公告)号：US10786429B2

公开(公告)日：2020-09-29

申请号：US16391588

申请日：2019-04-23

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: A61J1/14 ,  B01D39/16 ,  A61F9/00 ,  A61K9/00 ,  A61K9/08 ,  A61K31/5575 ,  A61K31/573 ,  A61K47/18

Abstract: A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.

公开(公告)号：US20160296476A1

公开(公告)日：2016-10-13

申请号：US15028496

申请日：2014-10-09

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Anuj Chauhan

IPC: A61K31/05 ,  A61K47/14 ,  A61K47/44 ,  A61K9/00 ,  A61K9/107

CPC classification number: A61K31/05 ,  A61K9/0019 ,  A61K9/107 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.

Abstract translation: 本文公开了包含生物活性剂的组合物; 基油; 可溶于基础油的另外的油，其生物活性分子的分配系数至少是基础油的两倍; 其中基础油和另外的油以组合物中存在的量有效地将水相中的生物活性剂的量减少至少于其量相同组合物中存在的基础油的80重量％ 在相同的总装油量; 非离子表面活性剂; 和水。