公开(公告)号：US20230211004A1

公开(公告)日：2023-07-06

申请号：US17778211

申请日：2020-11-22

申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

发明人： Paeton L. WANTUCH ,  Jeremy A. DUKE ,  Fikri Y. AVCI

IPC分类号： A61K47/64

CPC分类号： A61K47/646 ,  A61K47/6415

摘要： The present disclosure provides peptides derived from CRM197 and Tetanus toxoid that can be used to generate an immune response in an individual. The present disclosure includes isolated peptides and multimers of isolated peptides. Also provided are compositions that include the isolated peptide or the multimer. Further provided are methods, including methods for increasing the antigenicity of a compound, such as an antigen, and methods for inducing an immune response in a subject

公开(公告)号：US20230008380A1

公开(公告)日：2023-01-12

申请号：US17783379

申请日：2020-12-08

申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

发明人： Ahmet OZDILEK ,  Fikri Y. AVCI

IPC分类号： A61K39/04 ,  C07K14/35 ,  A61P31/06

摘要： The present disclosure provides isolated polynucleotides encoding a mature Mycobacterium tuberculosis protein selected from Ag85A, Ag85B, and Ag85C, where the protein does not include a signal for glycosylation, such as a N-glycosylation consensus sequon. Also disclosed are M. tuberculosis proteins selected from Ag85A, Ag85B, and Ag85C that do not include a signal for glycosylation, such as a N-glycosylation consensus sequon, and/or are not glycosylated, and methods for using the polynucleotides and proteins.