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公开(公告)号：US11806382B2
公开(公告)日：2023-11-07
申请号：US16951650
申请日：2020-11-18
发明人： Anil K. Chauhan , Nirav A. Dhanesha
IPC分类号： A61K38/10 , A61K38/39 , A61P9/10 , A61K38/18 , A61K38/17 , A61K38/19 , A61K39/395 , A61P29/00 , C07K16/28 , A61K39/00 , A61K9/00 , C07K14/47 , C07K7/08 , C07K14/78 , C07K14/46 , C07K14/705 , C07K14/52
CPC分类号： A61K38/10 , A61K38/1703 , A61K38/1709 , A61K38/1774 , A61K38/1866 , A61K38/19 , A61K38/39 , A61K39/3955 , A61P9/10 , A61P29/00 , A61K9/0019 , A61K2039/505 , A61K2039/54 , C07K7/08 , C07K14/46 , C07K14/47 , C07K14/4703 , C07K14/52 , C07K14/70503 , C07K14/78 , C07K16/2842 , C07K2317/76
摘要： The invention provides a method and kits for inhibiting integrin α9β1 activity comprising contacting integrin α9β1 or a binding partner of integrin α9β1 with an isolated anti-integrin α9 inhibitor, wherein the integrin α9β1 activity is inhibited. In certain aspects, the present invention provides a novel intervention by targeting integrin α9β1 with a functional blocking inhibitor (e.g., peptides or antibodies) to limit brain damage following reperfusion after ischemic stroke.
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公开(公告)号：US20240115653A1
公开(公告)日：2024-04-11
申请号：US18379847
申请日：2023-10-13
发明人： Anil K. Chauhan , Nirav A. Dhanesha
CPC分类号： A61K38/10 , A61K38/39 , A61P9/10 , C07K16/2842
摘要： The invention provides a method and kits for inhibiting integrin α9β1 activity comprising contacting integrin α9β1 or a binding partner of integrin α9β1 with an isolated anti-integrin α9 inhibitor, wherein the integrin α9β1 activity is inhibited. In certain aspects, the present invention provides a novel intervention by targeting integrin α9β1 with a functional blocking inhibitor (e.g., peptides or antibodies) to limit brain damage following reperfusion after ischemic stroke.
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公开(公告)号：US20210147556A1
公开(公告)日：2021-05-20
申请号：US16951650
申请日：2020-11-18
发明人： Anil K. Chauhan , Nirav A. Dhanesha
IPC分类号： C07K16/28 , A61K38/18 , A61K38/17 , A61K38/39 , A61K38/19 , A61K9/00 , A61P9/10 , A61K39/395
摘要： The invention provides a method and kits for inhibiting integrin α9β1 activity comprising contacting integrin α9β1 or a binding partner of integrin α9β1 with an isolated anti-integrin α9 inhibitor, wherein the integrin α9β1 activity is inhibited. In certain aspects, the present invention provides a novel intervention by targeting integrin α9β1 with a functional blocking inhibitor (e.g., peptides or antibodies) to limit brain damage following reperfusion after ischemic stroke.
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