公开(公告)号：US20230102047A1

公开(公告)日：2023-03-30

申请号：US17863135

申请日：2022-07-12

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S.J. BLAGG ,  Bhaskar Reddy KUSUMA ,  Teather SUNDSTROM

IPC: C07H15/207 ,  C07H15/203 ,  C07C211/17

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US20210188891A1

公开(公告)日：2021-06-24

申请号：US17112060

申请日：2020-12-04

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S.J. BLAGG ,  Bhaskar Reddy KUSUMA ,  Teather SUNDSTROM

IPC: C07H15/207 ,  C07H15/203 ,  C07C211/17

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US20190023730A1

公开(公告)日：2019-01-24

申请号：US16018401

申请日：2018-06-26

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S.J. BLAGG ,  Bhaskar Reddy KUSUMA ,  Teather SUNDSTROM

IPC: C07H15/207 ,  C07C211/17 ,  C07H15/203

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US20170051000A1

公开(公告)日：2017-02-23

申请号：US15227230

申请日：2016-08-03

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S.J. BLAGG ,  Bhaskar Reddy KUSUMA ,  Teather SUNDSTROM

IPC: C07H15/207 ,  C07C211/17

CPC classification number: C07H15/207 ,  C07C211/17 ,  C07H15/203

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

Abstract translation: 提供Hsp90 C末端抑制剂和含有这些化合物的药物组合物。 本公开的化合物可用于治疗和/或预防神经变性疾病如糖尿病性周围神经病变。

公开(公告)号：US20240417419A1

公开(公告)日：2024-12-19

申请号：US18667496

申请日：2024-05-17

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S.J. BLAGG ,  Bhaskar Reddy KUSUMA ,  Teather SUNDSTROM

IPC: C07H15/207 ,  C07C211/17 ,  C07H15/203

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US20200283465A1

公开(公告)日：2020-09-10

申请号：US16783025

申请日：2020-02-05

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S.J. BLAGG ,  Bhaskar Reddy KUSUMA ,  Teather SUNDSTROM

IPC: C07H15/207 ,  C07H15/203 ,  C07C211/17

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.