公开(公告)号：US20170100591A1

公开(公告)日：2017-04-13

申请号：US15387187

申请日：2016-12-21

Applicant: UNIVERSITY OF KANSAS ,  CASE WESTERN RESERVE UNIVERSITY

Inventor： Randolph J. Nudo ,  Pedram Mohseni ,  David Guggenmos ,  Meysam Azin

IPC: A61N1/36 ,  A61B5/00 ,  A61N1/05 ,  A61B5/04

CPC classification number: A61N1/36103 ,  A61B5/04001 ,  A61B5/6868 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0536 ,  A61N1/36139

Abstract: Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. The present disclosure provides, among other things, a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels.

公开(公告)号：US09533150B2

公开(公告)日：2017-01-03

申请号：US14630375

申请日：2015-02-24

Applicant: UNIVERSITY OF KANSAS ,  CASE WESTERN RESERVE UNIVERSITY

Inventor： Randolph J. Nudo ,  Pedram Mohseni ,  David Guggenmos ,  Meysam Azin

IPC: A61N1/05 ,  A61N1/36 ,  A61B5/00 ,  A61B5/04

CPC classification number: A61N1/36103 ,  A61B5/04001 ,  A61B5/6868 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0536 ,  A61N1/36139

Abstract: Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. The present disclosure provides, among other things, a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels.

Abstract translation: 提供了桥接基本上没有有效通信的脑部位置和相关联的神经修复装置的方法。 检测受试者中第一神经位点中的神经尖峰，并且在检测到神经穗之后的确定的时间段内传递对受试者中的第二神经部位的刺激，其中基本上没有有效的通信 第一和第二神经位点。 该方法在两个神经位点之间形成人造桥梁，并建立了两个站点之间的持久通信。 本公开尤其提供了包括集成电路的神经假体装置，所述集成电路包括包括多个记录通道的记录前端; 处理器单元; 以及传送后端的刺激物，其包括多个刺激通道。