公开(公告)号：US20190209007A1

公开(公告)日：2019-07-11

申请号：US16325765

申请日：2017-08-18

申请人： Paul S. D'URSO ,  Philip LEWIS

发明人： Paul S. D'URSO ,  Philip LEWIS

IPC分类号： A61B5/00 ,  A61N1/05 ,  A61B5/01 ,  A61B5/11

CPC分类号： A61B5/002 ,  A61B5/0008 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/031 ,  A61B5/04 ,  A61B5/061 ,  A61B5/076 ,  A61B5/1112 ,  A61B5/145 ,  A61B5/6803 ,  A61B5/6804 ,  A61B5/6805 ,  A61B5/6806 ,  A61B5/6831 ,  A61B5/6868 ,  A61B2560/0214 ,  A61B2562/164 ,  A61N1/0529 ,  A61N1/37229

摘要： Wearable medical devices and systems comprising the devices are provided. The devices and systems find use in monitoring and/or modulating the health of a wearer. The wearable devices may be personalized to conform to the external surface anatomy of the wearer and comprise one or more functional elements. The functional elements are positioned within the wearable device so as to maximize alignment or interaction with functional elements in one or more implanted medical devices or one or more internal anatomical features. The devices and systems find use in the delivery of health care.

公开(公告)号：US20190134402A1

公开(公告)日：2019-05-09

申请号：US16241524

申请日：2019-01-07

申请人： Michael Sasha John

发明人： Michael Sasha John

IPC分类号： A61N1/36 ,  A61N1/372

CPC分类号： A61N1/36178 ,  A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61N1/0456 ,  A61N1/0529 ,  A61N1/36064 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36114 ,  A61N1/37235

摘要： Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation modalities. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation, and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Novel methods are described for choosing, creating and subsequently stimulating with partial signals which summate to produce therapeutic vector fields having unique temporal patterns and low- or high-frequency spectral content. Improvements for the treatment of pain are disclosed.

公开(公告)号：US20180221652A1

公开(公告)日：2018-08-09

申请号：US15947755

申请日：2018-04-06

申请人： SORIN CRM SAS

发明人： Nicolas Shan ,  The-hoa Lai

IPC分类号： A61N1/05

CPC分类号： A61N1/0529 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/086 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071

摘要： A microlead, of an overall diameter less than 0.5 mm, includes a plurality of at least eight conductor wires individually insulated and twisted together. Each conductor wire includes an electrically conductive core microcable and an insulation layer surrounding the core microcable and having at least one exposed area to form a detection/stimulation electrode of the microlead. The microlead further includes a central support structure shaped as a surface of revolution, which may be free of conductor wires and of central lumen. The conductor wires are configured in one or more layers of twisted peripheral conductor wires carried by the central support structure and circumferentially distributed thereon.

公开(公告)号：US20180192952A1

公开(公告)日：2018-07-12

申请号：US15741081

申请日：2016-07-01

申请人： The Board of Trustees of the University of Illinois ,  Washington University in St. Louis

发明人： John A. ROGERS ,  Gunchul SHIN ,  Sung Il PARK ,  Robert GEREAU ,  Clinton MORGAN ,  Daniel BRENNER ,  Michael BRUCHAS ,  Jordan McCALL

IPC分类号： A61B5/00 ,  A61B5/01 ,  A61B5/04 ,  A61B5/07 ,  A61B5/03 ,  A61F7/12 ,  A61N1/05 ,  A61N1/372 ,  A61M31/00 ,  A61N1/378 ,  A61N5/06 ,  A61N1/375

CPC分类号： A61B5/686 ,  A61B5/0031 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/036 ,  A61B5/04 ,  A61B5/04001 ,  A61B5/042 ,  A61B5/076 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/407 ,  A61B5/4839 ,  A61B5/6868 ,  A61B5/6877 ,  A61B2503/40 ,  A61B2503/42 ,  A61B2560/0219 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/164 ,  A61B2562/222 ,  A61F7/12 ,  A61F2007/126 ,  A61M31/002 ,  A61M2205/3515 ,  A61M2205/3523 ,  A61M2205/8243 ,  A61N1/05 ,  A61N1/0529 ,  A61N1/0553 ,  A61N1/37229 ,  A61N1/37518 ,  A61N1/3787 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0612 ,  A61N2005/0651 ,  A61N2005/0652 ,  H01Q1/273 ,  H01Q5/35 ,  H01Q9/42 ,  H02J7/025 ,  H02J50/27 ,  H02J50/80 ,  H04B5/0037 ,  H05K1/0283 ,  H05K2201/09263 ,  H05K2201/10098

摘要： Provided are fully implantable soft medical devices and related methods. The devices comprise stretchable electronic devices between on an elastomeric substrate and an elastomeric super-state. Electronic components of the electronic device are configured to interface with tissue. Wireless power and control systems provide wireless power and control of the electronic components, thereby providing the fully implantable functionality. The devices may have a plurality of independently addressable electronic components, such as LEDs. In this manner, wireless control of a single implanted device may still provide multi-functional capabilities, including in a multiplexed configuration.

公开(公告)号：US09993640B2

公开(公告)日：2018-06-12

申请号：US14559045

申请日：2014-12-03

申请人： Neurohabilitation Corporation

发明人： Mark Guarraia ,  Aidan Petrie ,  Justin Fisk ,  Adam Muratori ,  Jeffrey M. Wallace ,  Jeffrey C. Morang

IPC分类号： A61N1/00 ,  A61N1/05 ,  A61N1/04 ,  A61N1/36

CPC分类号： A61N1/0548 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/0529 ,  A61N1/36014 ,  A61N1/36025

摘要： A mouthpiece for providing non-invasive neuromodulation to a patient. The mouthpiece includes an elongated housing having a center of gravity located within a posterior region, a positioning pad attached to the top surface of the elongated housing for minimizing contact between a patient's upper teeth and the exterior top surface of the elongated housing, and a printed circuit board mounted to a bottom portion of the elongated housing, the printed circuit board having a plurality of electrodes for delivering subcutaneous local electrical stimulation to the patient's tongue. In some embodiments, the mouthpiece includes at least one locator disposed along the anterior region of the elongated housing for contacting a patient's teeth to securely position the mouthpiece within the patient's mouth.

公开(公告)号：US09949376B2

公开(公告)日：2018-04-17

申请号：US14563778

申请日：2014-12-08

申请人： Second Sight Medical Products, Inc.

发明人： Robert J Greenberg ,  Neil H Talbot ,  James S Little

IPC分类号： A61N1/375 ,  A61N1/05 ,  A61N1/36 ,  A61N1/372 ,  H05K3/28 ,  H05K1/11 ,  H05K1/14 ,  A61B5/00 ,  A61B5/0478 ,  H05K1/18 ,  H01L23/055 ,  H05K1/02 ,  H05K1/03 ,  H05K1/09 ,  H05K3/00 ,  H05K3/32 ,  H05K3/36 ,  H05K3/40

CPC分类号： H05K3/282 ,  A61B5/0006 ,  A61B5/0478 ,  A61B5/4836 ,  A61B5/6868 ,  A61B2562/0209 ,  A61B2562/046 ,  A61B2562/125 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/375 ,  A61N1/3752 ,  A61N1/3754 ,  H01L23/055 ,  H01L2224/16225 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48465 ,  H05K1/02 ,  H05K1/0271 ,  H05K1/028 ,  H05K1/0281 ,  H05K1/0306 ,  H05K1/092 ,  H05K1/11 ,  H05K1/111 ,  H05K1/145 ,  H05K1/147 ,  H05K1/189 ,  H05K3/0044 ,  H05K3/005 ,  H05K3/0058 ,  H05K3/28 ,  H05K3/321 ,  H05K3/363 ,  H05K3/4015 ,  H05K3/4061 ,  H05K2201/0245 ,  H05K2201/053 ,  H05K2201/055 ,  H05K2201/09063 ,  H05K2201/09145 ,  H05K2201/09163 ,  H05K2201/097 ,  H05K2201/09981 ,  H05K2201/10303 ,  H05K2201/10318 ,  H05K2201/10674 ,  H05K2201/10795 ,  H05K2201/10931 ,  H05K2201/2009 ,  H05K2203/0195 ,  H05K2203/025 ,  H05K2203/0278 ,  H05K2203/0307 ,  H05K2203/068 ,  H05K2203/082 ,  H05K2203/1322 ,  H05K2203/1327 ,  H05K2203/1394 ,  H05K2203/1461 ,  H05K2203/1476 ,  H05K2203/162 ,  H05K2203/304 ,  H01L2924/00014 ,  H01L2924/00

摘要： The present invention consists of an implantable device with at least one package that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil attached to at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that are attached to the at least one package. The device is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals. A brain stimulator, preferably a deep brain stimulator, stimulates the brain in response to neural recordings in a closed feedback loop. The device is advantageous in providing neuromodulation therapies for neurological disorders such as chronic pain, post traumatic stress disorder (PTSD), major depression, or similar disorders. The invention and components thereof are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.

公开(公告)号：US09943690B2

公开(公告)日：2018-04-17

申请号：US15246351

申请日：2016-08-24

申请人： NeuroPace, Inc.

发明人： Benjamin D. Pless ,  Thomas K. Tcheng

IPC分类号： A61N1/00 ,  A61N1/36 ,  A61M5/142 ,  A61N1/05 ,  A61B5/00 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/07 ,  A61B5/021 ,  A61B5/026 ,  A61B5/0488 ,  A61B5/145

CPC分类号： A61N1/36135 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/026 ,  A61B5/04012 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/076 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/4812 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/743 ,  A61M5/14276 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0539 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36078 ,  A61N1/36139

摘要： An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.

公开(公告)号：US09907475B2

公开(公告)日：2018-03-06

申请号：US13805132

申请日：2011-06-16

申请人： Daryl R. Kipke ,  Takashi Daniel Yoshida Kozai ,  Nick Langhals ,  Joerg Lahann ,  Nicholas A. Kotov ,  Xiaopei Deng ,  Paras Patel

发明人： Daryl R. Kipke ,  Takashi Daniel Yoshida Kozai ,  Nick Langhals ,  Joerg Lahann ,  Nicholas A. Kotov ,  Xiaopei Deng ,  Paras Patel

IPC分类号： A61B5/04 ,  A61N1/00 ,  A61B5/00 ,  A61N1/05 ,  B82Y5/00

CPC分类号： A61B5/04001 ,  A61B5/685 ,  A61B2562/125 ,  A61N1/05 ,  A61N1/0529 ,  A61N1/0551 ,  B82Y5/00

摘要： The present disclosure provides robust implantable micro-component electrodes that can be used in a variety of medical devices. The medical device may be a neural probe that can monitor or stimulate neural activity in an organism's brain, spine, nerves, or organs, for example. The micro-component electrode has a small physical profile, with ultra-thin dimensions, while having high strength and flexibility. The micro-electrode has an electrically conductive core material, e.g., carbon. The surface of the core material includes one or more electrically conductive regions coated with an electrically conductive material and one or more non-conductive regions having an electrically non-conductive biocompatible polymeric coating. Implantable devices having such micro-components are capable of implantation in an organism for very long durations.

公开(公告)号：US09867988B2

公开(公告)日：2018-01-16

申请号：US14424966

申请日：2013-08-28

申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人： Wolfgang Fink ,  Erich Schmid

IPC分类号： A61N1/05 ,  A61N1/36

CPC分类号： A61N1/36182 ,  A61N1/0529 ,  A61N1/0543 ,  A61N1/0551 ,  A61N1/36046 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36185

摘要： This invention provides an apparatus for electrically stimulating a cell and a method for using the same. In particular, the apparatus of the invention comprises an array of electrodes and a controller for actuating individual electrodes.

公开(公告)号：US20170368339A1

公开(公告)日：2017-12-28

申请号：US15698393

申请日：2017-09-07

申请人： Dirk De Ridder

发明人： Dirk De Ridder

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61M5/142 ,  A61N2/00

CPC分类号： A61N1/3605 ,  A61M5/14276 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0553 ,  A61N1/36017 ,  A61N1/36021 ,  A61N1/36036 ,  A61N1/3606 ,  A61N1/36071 ,  A61N1/36085 ,  A61N1/36096 ,  A61N1/361 ,  A61N1/3611 ,  A61N1/36117 ,  A61N2/006

摘要： The present application relates to a new stimulation design which can be utilized to treat neurological conditions. The stimulation system produces a burst mode stimulation which alters the neuronal activity of the predetermined site, thereby treating the neurological condition or disorder. The burst stimulus comprises a plurality of groups of spike pulses having a maximum inter-spike interval of 100 milliseconds. The burst stimulus is separated by a substantially quiescent period of time between the plurality of groups of spike pulses. This inter-group interval may comprise a minimum of 5 seconds.