-
公开(公告)号：US20200171060A1
公开(公告)日：2020-06-04
申请号：US16629057
申请日：2018-01-26
发明人： KATHERINE L. RADTKE
IPC分类号： A61K31/683 , A61K45/06 , A61K31/506 , A61K31/675
摘要： The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.
-
公开(公告)号：US20220133756A1
公开(公告)日：2022-05-05
申请号：US17569804
申请日：2022-01-06
发明人： KATHERINE L. RADTKE
IPC分类号： A61K31/683 , A61K45/06 , A61K31/675 , A61K31/506
摘要： The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.
-
3.发明申请公开(公告)号：US20190160071A1
公开(公告)日：2019-05-30
申请号：US16264827
申请日：2019-02-01
发明人： KATHERINE L. RADTKE
IPC分类号： A61K31/519 , C07D487/04 , C07D495/04
摘要： The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds and prodrugs thereof that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
-
4.发明申请公开(公告)号：US20180161330A1
公开(公告)日：2018-06-14
申请号：US15893779
申请日：2018-02-12
IPC分类号： A61K31/519 , C07D487/04 , C07D495/04
CPC分类号： A61K31/519 , C07D487/04 , C07D495/04
摘要： The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
-
5.发明申请公开(公告)号：US20180015052A1
公开(公告)日：2018-01-18
申请号：US15546818
申请日：2016-01-28
申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY , KATHOLIEKE UNIVERSITEIT LEUVEN , LEIDEN UNIVERSITY MEDICAL CENTER
IPC分类号： A61K31/08 , A61K31/506 , A61K31/4178 , C07D403/04 , A61K45/06
CPC分类号： A61K31/08 , A61K31/4178 , A61K31/506 , A61K45/06 , A61K2300/00 , C07D403/04 , Y02P20/582
摘要： The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
-
6.发明申请THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF 审中-公开作为抗感染剂的苯丙酮和吡咯烷酮类似物及其使用方法公开(公告)号：US20170014415A1
公开(公告)日：2017-01-19
申请号：US15249980
申请日：2016-08-29
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , C07D487/04 , C07D495/04
摘要： The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
摘要翻译： 本发明提供了具有癌增殖抑制活性的卤代噻吩并吡咯并嘧啶化合物的设计和合成及其在癌症治疗中的应用。
-
7.发明申请公开(公告)号：US20190201352A1
公开(公告)日：2019-07-04
申请号：US16299379
申请日：2019-03-12
申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY , KATHOLIEKE UNIVERSITEIT LEUVEN , LEIDEN UNIVERSITY MEDICAL CENTER
IPC分类号： A61K31/08 , C07D403/04 , A61K45/06 , A61K31/506 , A61K31/4178
CPC分类号： A61K31/08 , A61K31/4178 , A61K31/506 , A61K45/06 , A61K2300/00 , C07D403/04 , Y02P20/582
摘要： The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
-
8.发明申请公开(公告)号：US20180303768A1
公开(公告)日：2018-10-25
申请号：US16025284
申请日：2018-07-02
IPC分类号： A61K31/08 , A61K31/506 , C07D403/04 , A61K45/06 , A61K31/4178
CPC分类号： A61K31/08 , A61K31/4178 , A61K31/506 , A61K45/06 , A61K2300/00 , C07D403/04 , Y02P20/582
摘要： The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
-
9.发明申请THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF 有权作为抗感染剂的苯丙酮和吡咯烷酮类似物及其使用方法公开(公告)号：US20160257696A1
公开(公告)日：2016-09-08
申请号：US14634940
申请日：2015-03-02
IPC分类号： C07D495/04 , C07D487/04
CPC分类号： A61K31/519 , C07D487/04 , C07D495/04
摘要： The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
摘要翻译： 本发明提供了表现出癌细胞增殖抑制活性的卤代噻吩并吡咯并嘧啶化合物的设计和合成及其在癌症治疗中的应用。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.018 秒)
