专利检索 ap:("UNIVERSITY OF MARYLAND, BALTIMORE COUNTY") AND inv:"Xiang Li" 第 1 页

1.

发明授权
PIM kinase inhibitors in combination with RNA splicing modulators/inhibitors for treatment of cancers 有权

公开(公告)号：US10525047B2

公开(公告)日：2020-01-07

申请号：US16082325

申请日：2017-03-22

申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY

发明人： Charles J. Bieberich , Xiang Li , Tejashree Joglekar

IPC分类号： A61K31/454 , A61K45/06 , A61K31/365 , A61P35/00 , G01N33/50

摘要： The present invention provides for a method of treating cancer and/or reducing proliferation of cancer cells, the method comprising administering to a subject in need of such treatment a composition comprising a PIM kinase inhibitor that exhibits changes of mRNA splicing in combination with a compound that modulates/inhibits activity of an RNA splicing factor protein. Further, changes in splicing of mRNAs and phosphorylation of RNA splicing factors can be used as biomarkers for patient responsiveness to anti-PIM treatment and also suggest effective combinatorial therapies, including synergistic combination.