公开(公告)号：US20240228552A9

公开(公告)日：2024-07-11

申请号：US18482052

申请日：2023-10-06

申请人： UNIVERSITY OF MASSACHUSETTS

发明人： Min Chen ,  Fanjun Li

IPC分类号： C07K14/245 ,  B82Y5/00 ,  C12N9/12 ,  C12Q1/48

CPC分类号： C07K14/245 ,  B82Y5/00 ,  C12N9/12 ,  C12Q1/485 ,  C12Y207/10001

摘要： Disclosed herein are nanopore tweezer systems that can be used to screen for allosteric inhibitors of protein kinases. In some embodiments, the protein kinase is a mutant kinase that confers resistance to chemotherapeutic drugs during cancer treatment. Therefore, the disclosed systems and methods can be used to identify drugs for treating drug resistant cancers.

公开(公告)号：US20240132551A1

公开(公告)日：2024-04-25

申请号：US18482052

申请日：2023-10-05

申请人： UNIVERSITY OF MASSACHUSETTS

发明人： Min Chen ,  Fanjun Li

IPC分类号： C07K14/245 ,  B82Y5/00 ,  C12N9/12 ,  C12Q1/48

CPC分类号： C07K14/245 ,  B82Y5/00 ,  C12N9/12 ,  C12Q1/485 ,  C12Y207/10001

摘要： Disclosed herein are nanopore tweezer systems that can be used to screen for allosteric inhibitors of protein kinases. In some embodiments, the protein kinase is a mutant kinase that confers resistance to chemotherapeutic drugs during cancer treatment. Therefore, the disclosed systems and methods can be used to identify drugs for treating drug resistant cancers.