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8 条记录 (耗时 0.041 秒)

    CANCER TREATMENT AND DIAGNOSIS
    3.
    发明申请
    CANCER TREATMENT AND DIAGNOSIS 审中-公开

    公开(公告)号：US20180169159A1

    公开(公告)日：2018-06-21

    申请号：US15735502

    申请日：2016-06-13

    申请人： UNIVERSITY OF MIAMI

    发明人： Glen N. Barber

    IPC分类号： A61K35/763 ,  A61P35/00 ,  G01N33/574

    CPC分类号： A61K35/763 ,  A61P35/00 ,  C12N2710/16633 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57492 ,  G01N2333/4706

    摘要： The present disclosure provides, in general, a method for selecting a therapy for treating cancer in a human subject and subsequently treating cancer in a subject, which includes isolating a cancer cell from a human subject having cancer, determining the functional activity of STING or cGAS in the cell; and selecting a therapy for the cancer based on the functional activity of the STING or cGAS in the cell. Also provided, if the functional activity of STING and/or cGAS is determined to be defective in the cell, the therapy selected is one that is effective at killing STING-deficient and/or cGAS-deficient cancer cells, e.g., therapy including administering to the subject an oncolytic virus.

    Cancer Treatment and Diagnosis
    5.
    发明申请
    Cancer Treatment and Diagnosis 审中-公开

    公开(公告)号：US20190314429A1

    公开(公告)日：2019-10-17

    申请号：US16284975

    申请日：2019-02-25

    申请人： University of Miami

    发明人： Glen N. Barber

    IPC分类号： A61K35/763 ,  A61P35/00 ,  C12Q1/6886 ,  G01N33/574

    摘要： The present disclosure provides, in general, a method for selecting a therapy for treating cancer in a human subject and subsequently treating cancer in a subject, which includes isolating a cancer cell from a human subject having cancer, determining the functional activity of STING or cGAS in the cell; and selecting a therapy for the cancer based on the functional activity of the STING or cGAS in the cell. Also provided, if the functional activity of STING and/or cGAS is determined to be defective in the cell, the therapy selected is one that is effective at killing STING-deficient and/or cGAS-deficient cancer cells, e.g., therapy including administering to the subject an oncolytic virus.

    Cancer treatment and diagnosis
    7.
    发明授权
    Cancer treatment and diagnosis 有权

    公开(公告)号：US10821142B2

    公开(公告)日：2020-11-03

    申请号：US16284975

    申请日：2019-02-25

    申请人： University of Miami

    发明人： Glen N. Barber

    IPC分类号： A61K35/763 ,  C12Q1/6886 ,  A61P35/00 ,  G01N33/574

    摘要： The present disclosure provides, in general, a method for selecting a therapy for treating cancer in a human subject and subsequently treating cancer in a subject, which includes isolating a cancer cell from a human subject having cancer, determining the functional activity of the innate immune regulator STimulator of INterferon Genes (STING) or the cellular nucleotidyltransferase, cyclic Guanosine Monophosphate (cGMP)-Adenosine Monophosphate (AMP) Synthase (cyclicGMP-AMP Synthase or cGAS) in the cell, and selecting a therapy for the cancer based on the functional activity of the STING or cGAS in the cell. Also provided, if the functional activity of STING and/or cGAS is determined to be defective in the cell, the therapy selected is one that is effective at killing STING-deficient and/or cGAS-deficient cancer cells, for example a therapy including administering to the subject an oncolytic virus.

    Recombinant VSV for the Treatment of Tumor Cells
    8.
    发明申请
    Recombinant VSV for the Treatment of Tumor Cells 审中-公开
    重组VSV治疗肿瘤细胞

    公开(公告)号：US20160022748A1

    公开(公告)日：2016-01-28

    申请号：US14812454

    申请日：2015-07-29

    申请人： University of Miami

    发明人： Glen N. Barber

    IPC分类号： A61K35/766 ,  A61K38/21

    CPC分类号： A61K35/766 ,  A61K38/2026 ,  A61K38/208 ,  A61K38/215 ,  A61K38/217 ,  A61K38/45 ,  A61K48/00 ,  A61K48/0058 ,  C07K14/5406 ,  C12N15/86 ,  C12N2760/20232 ,  C12N2760/20243

    摘要： The present invention relates to compositions and methods for the treatment of tumor and/or malignant and/or cancerous cells. The present invention provides VSV vectors comprising nucleic acid encoding a cytokine, such as interleukin or interferon, or a suicide gene, such as thymidine kinase, or other biological protein, such as heat shock protein gp96, or endostatin or angiostatin, wherein said VSV vectors exhibit greater oncolytic activity against the tumor and/or malignant and/or cancerous cell than a wild-type VSV vector. The present invention also provides methods of making such vectors, host cells, expression systems, and compositions comprising such VSV vectors, and viral particles comprising such VSV vectors. The present invention also provides methods for producing oncolytic activity in a tumor and/or malignant and/or cancerous cell comprising contacting said cell with a VSV vector of the present invention. The present invention also provides methods for suppressing tumor growth comprising contacting said tumor with a VSV vector of the present invention. The present invention also provides methods for eliciting an immune response to a tumor cell in an individual.

    摘要翻译： 本发明涉及用于治疗肿瘤和/或恶性和/或癌细胞的组合物和方法。 本发明提供了包含编码细胞因子如白细胞介素或干扰素或自杀基因如胸苷激酶或其它生物蛋白如热休克蛋白gp96或内皮抑素或血管抑素的VSV载体，其中所述VSV载体 与野生型VSV载体相比，对肿瘤和/或恶性和/或癌细胞表现出更大的溶瘤活性。 本发明还提供了制备这样的载体，宿主细胞，表达系统和包含这种VSV载体的组合物的方法以及包含这种VSV载体的病毒颗粒。 本发明还提供了在肿瘤和/或恶性和/或癌细胞中产生溶瘤活性的方法，包括使所述细胞与本发明的VSV载体接触。 本发明还提供抑制肿瘤生长的方法，包括使所述肿瘤与本发明的VSV载体接触。 本发明还提供了引发个体中肿瘤细胞的免疫应答的方法。