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    CANCER TREATMENT AND DIAGNOSIS
    4.
    发明申请
    CANCER TREATMENT AND DIAGNOSIS 审中-公开

    公开(公告)号：US20180169159A1

    公开(公告)日：2018-06-21

    申请号：US15735502

    申请日：2016-06-13

    申请人： UNIVERSITY OF MIAMI

    发明人： Glen N. Barber

    IPC分类号： A61K35/763 ,  A61P35/00 ,  G01N33/574

    CPC分类号： A61K35/763 ,  A61P35/00 ,  C12N2710/16633 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57492 ,  G01N2333/4706

    摘要： The present disclosure provides, in general, a method for selecting a therapy for treating cancer in a human subject and subsequently treating cancer in a subject, which includes isolating a cancer cell from a human subject having cancer, determining the functional activity of STING or cGAS in the cell; and selecting a therapy for the cancer based on the functional activity of the STING or cGAS in the cell. Also provided, if the functional activity of STING and/or cGAS is determined to be defective in the cell, the therapy selected is one that is effective at killing STING-deficient and/or cGAS-deficient cancer cells, e.g., therapy including administering to the subject an oncolytic virus.

    Insulated herpesvirus-derived gene expression cassettes for sustained and regulatable gene expression
    10.
    发明申请
    Insulated herpesvirus-derived gene expression cassettes for sustained and regulatable gene expression 有权
    用于持续和可调节基因表达的绝缘疱疹病毒来源的基因表达盒

    公开(公告)号：US20070154456A1

    公开(公告)日：2007-07-05

    申请号：US10590136

    申请日：2005-02-17

    申请人： David Bloom ,  Antonio Amelio

    发明人： David Bloom ,  Antonio Amelio

    IPC分类号： A61K48/00 ,  C12N15/86 ,  C12N15/861

    CPC分类号： A61K31/713 ,  A61K48/00 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/16611 ,  C12N2710/16622 ,  C12N2710/16633 ,  C12N2710/16642 ,  C12N2710/16643 ,  C12N2830/007 ,  C12N2830/40 ,  C12N2830/60

    摘要： Disclosed are genetic expression cassettes, and vector comprising them useful for the delivery of nucleic acid segments encoding selected therapeutic constructs (including for example, peptides, polypeptides, ribozymes, and catalytic RN molecules), to selected cells and tissues of vertebrate animals. The disclosed genetic constructs are useful in the development of gene therapy vectors, including for example, viral vectors such as HSV, retroviral, lentiviral, AV, and rAAV vectors. The expression cassettes disclosed herein provide new tools in the field of gene therapy, and for the treatment of mammalian, and in particular, human diseases, disorders, and dysfunctions. The disclosed compositions may be utilized in a variety of investigative, diagnostic and therapeutic regimens, including the prevention and treatment of a variety of human diseases.

    摘要翻译： 公开了遗传表达盒和包含它们的载体，其可用于将编码所选择的治疗构建体（包括例如肽，多肽，核酶和催化性RN分子）的核酸片段递送至脊椎动物的选定细胞和组织。 所公开的遗传构建体可用于开发基因治疗载体，包括例如病毒载体如HSV，逆转录病毒，慢病毒，AV和rAAV载体。 本文公开的表达盒提供了在基因治疗领域和用于治疗哺乳动物，特别是人类疾病，障碍和功能障碍领域的新工具。 所公开的组合物可以用于多种调查，诊断和治疗方案，包括预防和治疗各种人类疾病。