公开(公告)号：US20230064064A1

公开(公告)日：2023-03-02

申请号：US17823921

申请日：2022-08-31

Applicant: UNIVERSITY OF NORTH TEXAS ,  The University of Texas System

Inventor： Clement T. Y. CHAN ,  Faruck MORCOS ,  Xian-Li JIANG

IPC: C12N15/63 ,  G16B20/30

Abstract: A method can include receiving a protein sequence (S) of a hybrid repressor, determining an original compatibility score C(S), where the compatibility score C is a function of the protein sequence (S) and predicting, based on the compatibility score C, a performance of the hybrid repressor. The hybrid protein sequence includes a plurality of DNA-binding modules (DBMs) and a plurality of ligand-binding modules (LBMs).