公开(公告)号：US20240361312A1

公开(公告)日：2024-10-31

申请号：US18432672

申请日：2024-02-05

Applicant: UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, JAPAN

Inventor： Yoshiya TANAKA ,  Satoshi KUBO ,  Minoru SATOH

IPC: G01N33/564 ,  A61K31/57

CPC classification number: G01N33/564 ,  A61K31/57 ,  G01N2800/10 ,  G01N2800/104 ,  G01N2800/52

Abstract: The present invention provides a method for evaluating severity or prognosis of a patient with mixed connective tissue disease, which includes



1) a step of bringing a biological sample separated from a patient with mixed connective tissue disease into contact with a carrier in which an antigen containing one or more of component proteins of survival motor neuron complex or an antigenic partial peptide thereof is immobilized on a solid phase to form a complex of an autoantibody in the biological sample and the antigen immobilized on the solid phase,
2) a step of detecting the autoantibody in the complex of the autoantibody and the immobilized antigen, and
3) a step of associating the patient with a severe mixed connective tissue disease or a poor prognosis when the autoantibody is detected from the biological sample separated from the patient in step 2).