公开(公告)号：US11857648B2

公开(公告)日：2024-01-02

申请号：US16179817

申请日：2018-11-02

Applicant: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Dexing Zeng ,  Lingyi Sun ,  Yongkang Gai

IPC: A61K51/08 ,  C07K16/30 ,  C07K7/06 ,  C07K7/64 ,  G01N33/50 ,  G01N33/60 ,  A61K51/10 ,  A61K47/68 ,  C07D255/02 ,  C07D257/02 ,  A61K9/51

CPC classification number: A61K51/082 ,  A61K9/51 ,  A61K47/6893 ,  A61K51/1027 ,  C07D255/02 ,  C07D257/02 ,  C07K7/06 ,  C07K7/64 ,  C07K16/30 ,  G01N33/5008 ,  G01N33/60 ,  C07K2319/00

Abstract: The present invention provides a multivalent compound for targeted molecular imaging and/or targeted drug delivery, wherein two components or targeting molecules each interacts with one or more biomarkers on a cell. The present invention further provides a multifunctional chelator to combine the targeting molecules. The present invention also provides an in vitro high-throughput screening assay to determine the length of the spacer molecules. The present invention also relates to compounds/probes, kits and methods for use in targeted molecular imaging and/or targeted drug delivery.

公开(公告)号：US12029798B2

公开(公告)日：2024-07-09

申请号：US16179785

申请日：2018-11-02

Applicant: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Dexing Zeng ,  Lingyi Sun ,  Yongkang Gai

IPC: A61K51/08 ,  A61K9/51 ,  A61K47/68 ,  A61K51/10 ,  C07D255/02 ,  C07D257/02 ,  C07K7/06 ,  C07K7/64 ,  C07K16/30 ,  G01N33/50 ,  G01N33/60

CPC classification number: A61K51/082 ,  A61K9/51 ,  A61K47/6893 ,  A61K51/1027 ,  C07D255/02 ,  C07D257/02 ,  C07K7/06 ,  C07K7/64 ,  C07K16/30 ,  G01N33/5008 ,  G01N33/60 ,  C07K2319/00

Abstract: The present invention provides a method of targeted molecular imaging and/or targeted drug delivery, wherein two components or probes each interacts with one or more biomarkers on a cell and separately interact with each other to form a stable bond, such as a stable covalent bond. In certain non-limiting embodiments, at least one of the probes is photo-triggered to allow for bonding with at least one second probe. In certain non-limiting embodiments, the cell is a tumor or cancer cell. The present invention also relates to compounds, probes, and kits for use in targeted molecular imaging and/or targeted drug delivery.