公开(公告)号：US20230226116A1

公开(公告)日：2023-07-20

申请号：US18046930

申请日：2022-10-16

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Steven A. GOLDMAN ,  John MARIANI ,  Nguyen P.T. HUYNH

IPC: A61K35/30 ,  C12N5/079 ,  C12N15/90 ,  C12N15/11 ,  C12N9/22 ,  A61P25/28

CPC classification number: A61K35/30 ,  C12N5/0622 ,  C12N15/907 ,  C12N15/11 ,  C12N9/22 ,  A61P25/28 ,  C12N2506/02 ,  C12N2310/20 ,  C12N2800/80

Abstract: A method for rejuvenating glial progenitor cells and rejuvenated glial progenitor cells rejuvenated by such method are disclosed. The method comprises introducing a population of genetically modified glial progenitor cells into the brain and/or brain stem of a subject, wherein the genetically modified glial progenitor cells have increased expression of one or more genes compared to the same type of glial progenitor cells that have not been genetically modified, and wherein the one or more genes are selected from the group consisting of ARX, CEBPZ, DLX1, DLX2, ELK1, ETS1, ETV4, KLF16, MYBL2, MYC, NFYB, POU3F1, SMAD1, SOX3, SP5, TCF12, TFDP1, TP53, ZIC3 and ZNF195.