专利检索 ap:("UNIVERSITY OF ROCHESTER" OR "UNIVERSITY OF COPENHAGEN") AND inv:"Ricardo de Costa Barbedo VIEIRA" 第 1 页

1.

发明公开
HUMANIZED CHIMERAS FOR THE PROSPECTIVE ASSESSMENT OF CELL ADDITION AND REPLACEMENT THERAPIES 审中-公开

公开(公告)号：US20230292719A1

公开(公告)日：2023-09-21

申请号：US18045148

申请日：2022-10-08

申请人： UNIVERSITY OF ROCHESTER , UNIVERSITY OF COPENHAGEN

发明人： Steven A. GOLDMAN , Ricardo de Costa Barbedo VIEIRA

IPC分类号： A01K67/027

CPC分类号： A01K67/0271 , A01K2207/15 , A01K2227/105 , A01K2267/0318

摘要： A chimeric non-human mammal disease model, wherein (1) at least 30% of all the glial cells in the corpus callosum of the chimeric non-human mammal are human glial cells, and/or (2) at least 5% of all of the glial cells in the white matter of the brain and/or brain stem of the chimeric non-human mammal are human glial cells, and wherein the human glial cells comprise a combination of a first group of human glial cells tagged with a first label and a second group of human glial cells tagged with a second label that is distinguishable from the first label.