公开(公告)号：US20230292719A1

公开(公告)日：2023-09-21

申请号：US18045148

申请日：2022-10-08

申请人： UNIVERSITY OF ROCHESTER ,  UNIVERSITY OF COPENHAGEN

发明人： Steven A. GOLDMAN ,  Ricardo de Costa Barbedo VIEIRA

IPC分类号： A01K67/027

CPC分类号： A01K67/0271 ,  A01K2207/15 ,  A01K2227/105 ,  A01K2267/0318

摘要： A chimeric non-human mammal disease model, wherein (1) at least 30% of all the glial cells in the corpus callosum of the chimeric non-human mammal are human glial cells, and/or (2) at least 5% of all of the glial cells in the white matter of the brain and/or brain stem of the chimeric non-human mammal are human glial cells, and wherein the human glial cells comprise a combination of a first group of human glial cells tagged with a first label and a second group of human glial cells tagged with a second label that is distinguishable from the first label.

公开(公告)号：US11733232B2

公开(公告)日：2023-08-22

申请号：US16490145

申请日：2018-03-01

申请人： National University Corporation Hokkaido University

发明人： Masaaki Murakami ,  Daisuke Kamimura ,  Yasunobu Arima

IPC分类号： G01N33/50 ,  A01K67/027

CPC分类号： G01N33/5008 ,  A01K67/027 ,  A01K2267/0318 ,  A01K2267/0356 ,  A01K2267/0368 ,  A01K2267/0375

摘要： [Problem] The objectives of the present invention are to provide a method for making an animal that has been stressed, in particular, chronically stressed, affect or develop a specific disease or symptom, and, through elucidating the process from loading stress to affection or onset of the disease or symptom, to provide a useful tool for research and development of preventing or treating methods of the disease or symptom. [Solution] The present invention relates to a method for producing a disease modeling non-human animal having cerebrovascular inflammation, the disease modeling non-human animal, a method for screening a drug using the disease modeling non-human animal, a method for determining the risk of a disease using the presence of cerebrovascular inflammation as an indicator, and a pharmaceutical for preventing and/or treating progressive multiple sclerosis or the like. The present invention enables developing pharmaceuticals for the above described diseases or the like and performing researches for elucidating their pathogenic mechanisms. The present invention also enables determining the risk of affection or onset of progressive multiple sclerosis or the like and preventing and/or treating progressive multiple sclerosis or the like.

公开(公告)号：US20190183102A1

公开(公告)日：2019-06-20

申请号：US16178949

申请日：2018-11-02

申请人： Universite de Paris - Sud ,  Universite Paris Descartes

发明人： Nathalie Cartier-Lacave ,  Jerome Braudeau ,  Nicole Deglon ,  Philippe Hantraye ,  Mickael Audrain

IPC分类号： A01K67/027 ,  G01N33/50 ,  C12N15/85 ,  C12N15/86

CPC分类号： A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0312 ,  A01K2267/0318 ,  C07K14/4711 ,  C12N15/8509 ,  C12N15/86 ,  C12N2015/8545 ,  C12N2750/14143 ,  G01N33/5088 ,  G01N2333/47

摘要： The present invention relates to a vector comprising a nucleic acid sequence that encodes the APP protein and/or the PS1 protein or variants thereof. The invention also relates to a method for inducing the Alzheimer's disease in an animal using the vector of the invention and to animal model having the Alzheimer's disease obtained by said method.

公开(公告)号：US20180264140A1

公开(公告)日：2018-09-20

申请号：US15576587

申请日：2016-05-24

申请人： SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人： Neal Dilip AMIN

IPC分类号： A61K48/00 ,  A61P25/28

CPC分类号： A61K48/0066 ,  A01K67/0275 ,  A01K67/0276 ,  A01K2217/052 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2227/50 ,  A01K2267/0318 ,  A01K2267/0393 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K48/0016 ,  A61P25/28 ,  C12N15/113 ,  C12N15/85 ,  C12N2310/113 ,  C12N2310/20 ,  C12N2830/008

摘要： The present disclosure relates to nucleic acid promoter sequences that are able to specifically express genes operatively linked to the promoter in brainstem and spinal motor neuron cells, and to methods for using such promoters to selectively express genes in motor neurons in vitro and in vivo. It is based, at least in part, on the discovery that the nucleic acid of SEQ ID NO: 1 functioned as a motor neuron-specific promoter and was successful in expressing transgenes in motor neuron cells in vivo. The present disclosure also relates to compositions that can increase the activity or expression level of miR-218 and to compositions that can decrease the expression of miR-218 target nucleic acids.

公开(公告)号：US20180117090A1

公开(公告)日：2018-05-03

申请号：US15857270

申请日：2017-12-28

申请人： Taiwan Mitochondrion Applied Technology Co., Ltd

发明人： Shinn-Zong LIN ,  Horng-Jyh HARN ,  Shih-Ping LIU ,  Han-Chung CHENG ,  Chi-Tang TU

IPC分类号： A61K35/28 ,  C12N5/0775 ,  C07K14/575 ,  A61P25/16 ,  A61K9/00

CPC分类号： A61K35/28 ,  A01K67/027 ,  A01K2207/20 ,  A01K2227/105 ,  A01K2267/0318 ,  A61K9/0019 ,  A61K9/0085 ,  A61K35/35 ,  A61K35/50 ,  A61K36/232 ,  A61K38/185 ,  A61P25/16 ,  C07K14/575 ,  C12N5/0667 ,  C12N2500/16 ,  C12N2500/30 ,  C12N2500/38 ,  C12N2500/76 ,  C12N2501/11 ,  C12N2501/999 ,  C12N2506/13 ,  C12N2506/1369

摘要： A cell for treating neurodegenerative disease treated with angelica extract is provided. The pharmaceutical composition comprises the cell for treating neurodegenerative disease and can significantly increase and recover the number of dopaminergic neurons to achieve the goal for treating neurodegenerative disease.

公开(公告)号：US09757402B2

公开(公告)日：2017-09-12

申请号：US14855645

申请日：2015-09-16

申请人： KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP

发明人： Seung-Jae Lee ,  He-Jin Lee ,  Eun-Jin Bae ,  Dong Kyu Kim

IPC分类号： C12N15/00 ,  G01N33/52 ,  A61K31/7008 ,  A01K67/033 ,  A61K49/00 ,  A61K31/00 ,  G01N33/50

CPC分类号： A61K31/7008 ,  A01K67/0336 ,  A01K2217/052 ,  A01K2217/15 ,  A01K2217/206 ,  A01K2227/703 ,  A01K2267/0318 ,  A01K2267/0393 ,  A61K31/00 ,  A61K49/0008 ,  A61K49/0045 ,  G01N33/5058 ,  G01N2500/10 ,  G01N2800/28

摘要： The present disclosure relates to dual-cell model and Caenorhabditis elegans model systems for measuring neuron-to-neuron transmission of protein aggregates, and more particularly to transgenic cell and animal model systems expressing fusion proteins of N-terminus or C-terminus of fluorescent proteins with α-synuclein proteins, methods for measuring continuous cell-to-cell transmission of α-synuclein aggregates using the same, and methods for screening substances for preventing or treating neurodegenerative diseases.

公开(公告)号：US09669112B2

公开(公告)日：2017-06-06

申请号：US14646429

申请日：2013-11-20

申请人： The J. David Gladstone Institutes

发明人： Katerina Akassoglou ,  Jae Kyu Ryu

IPC分类号： A01K67/00 ,  A61K49/00 ,  C07K14/75 ,  A01K67/027

CPC分类号： A61K49/0008 ,  A01K67/027 ,  A01K2207/10 ,  A01K2227/105 ,  A01K2267/0318 ,  A01K2267/035 ,  C07K14/75

摘要： The present invention provides non-human animal models of neuronal injury and/or cognitive dysfunction and methods of making and using such animal models. The animal models of the invention are particularly suited to assessing neurodegeneration in selected regions of interest in the CNS, and thus especially useful for testing the therapeutic efficacy of agents targeting neurodegeneration associated with aging, neurodegenerative diseases, autoimmunity and trauma (e.g., ischemia).

公开(公告)号：US20170028021A1

公开(公告)日：2017-02-02

申请号：US15222494

申请日：2016-07-28

申请人： MYELIN THERAPEUTICS, INC.

发明人： Matias Alvarez-Saavedra

IPC分类号： A61K38/18 ,  A61K48/00 ,  C12N7/00 ,  G01N33/68 ,  C12N15/86 ,  A61K38/46 ,  A61K9/00

CPC分类号： A61K38/18 ,  A01K2227/105 ,  A01K2267/0318 ,  A61K9/0085 ,  A61K38/465 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2750/14143 ,  C12Y301/00 ,  G01N33/6872 ,  G01N2333/47 ,  G01N2333/475

摘要： The disclosure provides for compositions and methods for treating neurodegenerative and cardiovascular disease in a subject. The compositions and methods include delivering a nucleic acid molecule encoding VGF or a peptide thereof to a subject. The disclosure further provides methods for the diagnosis of neurodegenerative and cardiovascular disease.

摘要翻译： 本公开提供了用于治疗受试者的神经变性和心血管疾病的组合物和方法。 组合物和方法包括将编码VGF或其肽的核酸分子递送至受试者。 本公开还提供了用于诊断神经变性和心血管疾病的方法。

公开(公告)号：US20170002064A1

公开(公告)日：2017-01-05

申请号：US15034766

申请日：2014-11-07

申请人： The Board of Regents of the University of Texas System

发明人： Nancy MONSON

IPC分类号： C07K16/18 ,  A61K31/713 ,  A01K67/027 ,  A61K49/00 ,  G01N33/68

CPC分类号： C07K16/18 ,  A01K67/0278 ,  A01K2207/10 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/0318 ,  A61K31/713 ,  A61K49/0004 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/6896 ,  G01N2800/285

摘要： Monoclonal antibodies exhibiting an VH4 signature associated with multiple sclerosis (MS) and clinically isolated syndrome have been produced and sequenced. These antibodies antibodies recognize neuronal nuclei and/or astrocytes in both mouse and human gray matter (GM) brain tissue and thus are useful in binding assays for such. They are also useful in the production of MS animal models, and as targets for MS therapies.

摘要翻译： 已经产生并测序表现出与多发性硬化（MS）和临床孤立综合征相关的VH4特征的单克隆抗体。 这些抗体抗体识别小鼠和人灰质（GM）脑组织中的神经元核和/或星形胶质细胞，因此可用于结合测定。 它们也可用于生产MS动物模型，并用作MS疗法的靶标。

公开(公告)号：US20160338327A1

公开(公告)日：2016-11-24

申请号：US15112136

申请日：2015-01-16

申请人： PATH THERAPEUTICS, INC.

发明人： Deborah M. KURRASCH ,  Jong RHO ,  Kingsley IBHAZEHIEBO

IPC分类号： A01K67/027 ,  C12N15/113 ,  A61K49/00

CPC分类号： A01K67/0278 ,  A01K2207/05 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2227/40 ,  A01K2267/0318 ,  A61K49/0008 ,  C12N15/113 ,  C12N2310/3233

摘要： The present application provides a novel drug screening platform designed to identify drugs that favorably modulate cellular bioenergetics in the human brain of a zebrafish which has been modified by altering a teleost gene that corresponds to a human gene associated with a brain dysfunction disorder (such as epilepsy). The drug screening platform are also useful for determining a mutation in a human gene associated with a brain dysfunction disorder that is associated with a human individual responsive to the treatment of a compound. Also provided are modified teleosts useful for the methods described herein.

摘要翻译： 本申请提供了一种新的药物筛选平台，其设计用于鉴定通过改变对应于与脑功能障碍障碍（例如癫痫）相关的人基因的硬骨架基因修饰的斑马鱼的人脑中的细胞生物能量的有利调节的药物 ）。 药物筛选平台也可用于确定与对处理化合物有反应的人类个体相关的脑功能障碍障碍的人类基因突变。 还提供了对本文描述的方法有用的修饰硬骨架。