公开(公告)号：US20210346498A1

公开(公告)日：2021-11-11

申请号：US17359496

申请日：2021-06-25

Applicant: UNIVERSITY OF SOUTHAMPTON

Inventor： Mark Cragg ,  Martin Glennie ,  Ali Roghanian ,  Stephen Beers ,  Peter Johnson ,  Sean Lim ,  Björn Frendéus ,  Ingrid Teige

IPC: A61K39/395 ,  C07K16/28 ,  G01N33/68

Abstract: The invention provides a method of treating a patient having target cells that express FcγRIIb, the method comprising administering (i) an antibody molecule that specifically binds a surface antigen of the target cell, which antibody molecule has an Fc domain capable of binding FcγRIIb; in combination with (ii) an agent that prevents or reduces binding between the Fc domain of the antibody molecule and FcγRIIb; characterized in that the patient is selected on the basis that their target cells express an elevated level of FcγRIIb.