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公开(公告)号：US20210346498A1
公开(公告)日：2021-11-11
申请号：US17359496
申请日：2021-06-25
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Mark Cragg , Martin Glennie , Ali Roghanian , Stephen Beers , Peter Johnson , Sean Lim , Björn Frendéus , Ingrid Teige
IPC: A61K39/395 , C07K16/28 , G01N33/68
Abstract: The invention provides a method of treating a patient having target cells that express FcγRIIb, the method comprising administering (i) an antibody molecule that specifically binds a surface antigen of the target cell, which antibody molecule has an Fc domain capable of binding FcγRIIb; in combination with (ii) an agent that prevents or reduces binding between the Fc domain of the antibody molecule and FcγRIIb; characterized in that the patient is selected on the basis that their target cells express an elevated level of FcγRIIb.
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公开(公告)号：US20230381310A1
公开(公告)日：2023-11-30
申请号：US18177050
申请日：2023-03-01
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Mark Cragg , Martin Glennie , Ali Roghanian , Stephen Beers , Peter Johnson , Sean Lim , Bjorn Frendeus , Ingrid Teige
IPC: A61K39/395 , C07K16/28 , G01N33/68
CPC classification number: A61K39/39558 , C07K16/283 , C07K16/2887 , C07K16/2803 , G01N33/6893 , A61K2039/507
Abstract: The invention provides a method of treating a patient having target cells that express FcγRIIb, the method comprising administering (i) an antibody molecule that specifically binds a surface antigen of the target cell, which antibody molecule has an Fc domain capable of binding FcγRIIb; in combination with (ii) an agent that prevents or reduces binding between the Fc domain of the antibody molecule and FcγRIIb; characterized in that the patient is selected on the basis that their target cells express an elevated level of FcγRIIb.
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公开(公告)号：US11623005B2
公开(公告)日：2023-04-11
申请号：US16684450
申请日：2019-11-14
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Mark Cragg , Martin Glennie , Ali Roghanian , Stephen Beers , Peter Johnson , Sean Lim , Bjorn Frendeus , Ingrid Teige
Abstract: The invention provides a method of treating a patient having target cells that express FcγRIIb, the method comprising administering (i) an antibody molecule that specifically binds a surface antigen of the target cell, which antibody molecule has an Fc domain capable of binding FcγRIIb; in combination with (ii) an agent that prevents or reduces binding between the Fc domain of the antibody molecule and FcγRIIb; characterized in that the patient is selected on the basis that their target cells express an elevated level of FcγRIIb.
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公开(公告)号：US20200069798A1
公开(公告)日：2020-03-05
申请号：US16684450
申请日：2019-11-14
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Mark Cragg , Martin Glennie , Ali Roghanian , Stephen Beers , Peter Johnson , Sean Lim , Bjorn Frendeus , Ingrid Teige
IPC: A61K39/395 , G01N33/68 , C07K16/28
Abstract: The invention provides a method of treating a patient having target cells that express FcγRIIb, the method comprising administering (i) an antibody molecule that specifically binds a surface antigen of the target cell, which antibody molecule has an Fc domain capable of binding FcγRIIb; in combination with (ii) an agent that prevents or reduces binding between the Fc domain of the antibody molecule and FcγRIIb; characterized in that the patient is selected on the basis that their target cells express an elevated level of FcγRIIb.
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