公开(公告)号：US20200178517A1

公开(公告)日：2020-06-11

申请号：US16619676

申请日：2018-06-05

Applicant: THE UNIVERSITY OF WARWICK

Inventor： Matthew I. GIBSON ,  Ben GRAHAM ,  Trisha L. BAILEY

IPC: A01N1/02 ,  C07K7/06 ,  C07K7/08 ,  A23L3/37 ,  A23G9/38 ,  A23B4/08 ,  A23B7/05

Abstract: The present invention relates to methods for preventing or inhibiting ice recrystallisation in substances (e.g. biological materials and food products) which are susceptible to ice crystal growth upon cryopreservation and/or thawing therefrom. The methods relate to the use of compositions comprising poly(proline) or a variant or derivative thereof. Also provided are kits and compositions comprising poly(proline) which can be used in the methods of the invention.

公开(公告)号：US20190059360A1

公开(公告)日：2019-02-28

申请号：US16018555

申请日：2018-06-26

Applicant: UNIVERSITY OF WARWICK

Inventor： Matthew I. GIBSON ,  Robert C. DELLER

IPC: A01N1/02

Abstract: The present invention relates to a method for cryopreserving biological material. In particular, the method comprises storing the biological material at a cryopreserving temperature in a composition comprising polyvinyl alcohol (PVA), wherein the composition is substantially free of vitrification-inducing agents such as DMSO and glycerol. The invention also provides methods of inhibiting ice recrystallisation and of reducing cell damage during the warming or thawing of a cryopreserved composition comprising biological material. The invention also relates to processes for producing a biological material, and related kits.