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    Antibiotic armentomycin and a process for producing the same
    4.
    发明授权
    Antibiotic armentomycin and a process for producing the same 失效
    抗生素弓形体霉素及其制备方法

    公开(公告)号：US3342681A

    公开(公告)日：1967-09-19

    申请号：US44861165

    申请日：1965-04-16

    Applicant: UPJOHN CO

    Inventor： ARGOUDELIS ALEXANDER D ,  HERR ROSS R ,  MASON DONALD J

    IPC: A01N63/02 ,  C07G11/00 ,  C12P13/04 ,  G03F7/34

    CPC classification number: A61K31/70 ,  C10M1/08 ,  C10M2215/04 ,  C10M2215/26 ,  C10N2240/401 ,  C10N2250/121 ,  C12P13/04 ,  Y10S435/886

    Abstract: 1,131,079. Armentomycin. UPJOHN CO. 25 March, 1966 [16 April, 1965], No. 13338/66. Heading C2A. [Also in Divisions A5, C5 and D2] The invention relates to the new antibiotic, armentomycin, which inhibits the growth of Gram-negative bacteria and has the following properties: Empirical formula, C 4 H 7 Cl 2 NO 2 ; an analysis, C-28À39%, H-4À44%, N-9À09%, Cl-40À60%, and O-17À48%; a calculated mol. wt. of 172; an equivalent weight of 168 by KOH titration and 174 by perchloric acid titration; an optical rotation [α] 25 D = +6À7‹ (C. 0À74 in water) and [α] 25 D = 26À240 (C. 0À74 in water at pH 1À0); a pKa of 8À28; no U.V. maxima between 220 and 400 mÁ; an I.R. spectrum as in Fig. 1 above; and is soluble in water, methanol and ethanol, and insoluble in methylene chloride, acetone and non-polar solvents. Armentomycin is amphoteric and forms acid addition salts and salts with bases. Salts include those with physiologically active bases, e.g. theophylline, theobromine, caffeine, antihistamine bases, nicotinamide, nicotinic acid hydrazide, adrenalin, ephedrine, and choline, and also with sodium, potassium and calcium. The antibiotic is produced by aerobic submerged cultivation of the new microorganism, Streptomyces armentosus var. armentosus, NRRL.3176, in aqueous nutrient medium containing sources of assimilable carbon and nitrogen. H may be isolated from the fermentation broth by, e.g. solvent extraction, liquidliquid distribution, adsorption on ion-exchange resins or surface-active agents, and purified by crystallization from mixed solvents.

    Antibiotic process of treatment
    7.
    发明授权
    Antibiotic process of treatment 失效
    抗生素治疗过程

    公开(公告)号：US3679787A

    公开(公告)日：1972-07-25

    申请号：US3679787D

    申请日：1970-08-06

    Applicant: UPJOHN CO

    Inventor： BERGY MALCOLM E ,  HERR ROSS R ,  MASON DONALD J

    IPC: A61K31/70 ,  A61K21/00

    CPC classification number: A61K31/70

    Abstract: The combination of lincomycin and spectinomycin, in unit dosage form, in combination with pharmaceutical carriers: useful in treating diseased animals and exhibiting synergistic activity against mycoplasma infections e.g. PPLO and L forms.

    Abstract translation: 林可霉素和壮观霉素的组合，单位剂型与药物载体的组合：可用于治疗患病动物并显示出针对支原体感染的协同作用。 PPLO和L形式。

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