公开(公告)号：US3255183A

公开(公告)日：1966-06-07

申请号：US34734864

申请日：1964-02-26

Applicant: UPJOHN CO

Inventor： LORENTZ WILLIAM D ,  FORSBLAD INGEMAR B

IPC: C07J5/00 ,  C07J13/00 ,  C07J21/00 ,  C07J75/00

CPC classification number: C07J21/00 ,  C07J5/00 ,  C07J13/00 ,  C07J75/00

公开(公告)号：US3583979A

公开(公告)日：1971-06-08

申请号：US3583979D

申请日：1969-05-06

Applicant: UPJOHN CO

Inventor： LORENTZ WILLIAM D ,  BEAL PHILIP F ,  PARIKH JEKISHAN R

IPC: C07D295/30 ,  C07D41/04

CPC classification number: C07D295/30

Abstract: THIS INVENTION RELATES TO A NOVEL PROCESS FOR THE PREPARATION OF N-AMINOHEXAMETHYLENEIMINE OF THE FORMULA

1-NH2-HEXAHYDROAZEPINE

WHICH COMPRISES HEATING N-NITROSOHEXAMETHYLENEIMINE OF THE FORMULA

1-(O=N-)-HEXAHYDROAZEPINE

IN A LOWER-ALKANOL-WATER CONTAINING A BASE AND AN ALKALI METAL HYDROSULFITE. N-AMINOHEXAMETHYLENEIMINE (I) IS A MAJOR REACTANT IN THE SYNTHESIS OF 1-(HEXAHYDRO-1HAZEPIN - 1 - YL) - 3 - (P-TOLYSULFONYL) UREA, THE ORAL ANTIDIABETIC DRUG TOLAZAMIDE.